The Interplay Between Nutrition, Fasting, and Metabolic Health

Dear Colleagues,

This Special Issue, "The Interplay Between Nutrition, Fasting, and Metabolic Health," focuses on the synergistic effects of different fasting patterns and nutritional factors, thoroughly exploring their mechanisms and impacts on metabolic regulation. We will systematically investigate various fasting strategies—including intermittent fasting (time-restricted eating and alternate-day fasting), periodic fasting (5:2 diet and fasting-mimicking diet), and prolonged fasting—with particular emphasis on how these dietary patterns influence body health through nutritional pathways such as nutrient metabolism, energy balance, and gut microbiota.

Key nutritional topics of interest include the following:

• Metabolic adaptation mechanisms of macronutrients under different fasting regimens;
• Interactive effects of dietary patterns and fasting cycles on metabolic flexibility;
• Synergistic role of specific nutrients (e.g., polyphenols and dietary fiber) in metabolic regulation during fasting periods;
• Combined effects of fasting and nutritional interventions on metabolic syndrome-related parameters (body composition, glucose homeostasis, and lipid profile).

We welcome human studies across different life stages, physical activity levels, and metabolic backgrounds, including observational studies, randomized controlled trials, systematic reviews, and mechanistic investigations. By integrating the intersecting fields of nutritional science and fasting research, this issue aims to provide theoretical foundations and practical guidance for precision nutrition interventions.

Dr. Robin Mesnage
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.