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Diet and Metabolism in Chronic Liver Disease: Interventions from Primary Care and Public Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 1718

Editors


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Guest Editor
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08303 Mataró, Spain
Interests: chronic liver disease; hepatic fibrosis; non-alcoholic fatty liver disease; preventive medicine; primary care interventions; public health
Special Issues, Collections and Topics in MDPI journals

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Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08303 Mataró, Spain
Interests: chronic liver disease; preventive medicine; primary care interventions; atheroesclerosis; aging and longevity; COVID-19

Special Issue Information

Dear Colleagues,

Chronic liver disease is a major global health challenge, ranking as the 12th leading cause of mortality and responsible for about 2.3 million deaths in 2021. A major contributor is metabolic dysfunction-associated steatotic liver disease (MASLD), strongly linked to obesity, type 2 diabetes, and dyslipidemia, and affecting nearly one-third of adults worldwide. The adverse consequences of MASLD are largely preventable through effective control of metabolic risk factors. Understanding the relationship between diet, metabolism, and the progression of chronic liver disease is therefore essential for developing preventive and therapeutic strategies.

This Special Issue of Nutrients, “Diet and Metabolism in Chronic Liver Disease: Interventions from Primary Care and Public Health”, will highlight original contributions on the role of nutrition in managing this condition. We welcome research articles, reviews, and clinical cases examining how dietary interventions and metabolic changes influence prevention, diagnosis, and treatment. The aim is to provide a comprehensive perspective that spans basic research, clinical applications, and public health strategies. This Special Issue will be of particular interest to researchers, nutritionists, primary care physicians, and public health professionals, emphasizing the importance of a multidisciplinary and preventive approach in addressing chronic liver disease.

Dr. Pere Torán-Monserrat
Guest Editors

Dr. Noemí Lamonja-Vicente
Meritxell Carmona-Cervelló
Guest Editors Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic liver disease
  • metabolism
  • diet
  • primary care
  • public health
  • obesity
  • insulin resistance
  • nutrition
  • non-alcoholic fatty liver disease
  • hepatic fibrosis

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Published Papers (1 paper)

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Research

16 pages, 1038 KB  
Article
Sex Differences in Older Adults with Risky Alcohol Consumption: Medication Use, Comorbidities, and Hepatic Biomarkers
by Ingrid Arteaga, Meritxell Carmona-Cervelló, Guillem Pera, Carla Chacón, Galadriel Diez-Fadrique, Irene Ruiz-Rojano, Maria Palau-Antoja, Faranak Nooriankafshgari, Cristina Vedia, Pilar Montero-Alía, Maria Carmen Rodríguez-Pérez, Susana Montesinos and Pere Torán-Monserrat
Nutrients 2026, 18(14), 2346; https://doi.org/10.3390/nu18142346 - 17 Jul 2026
Viewed by 1352
Abstract
Background/Objectives: Alcohol consumption and medication use have increased among older population, potentially increasing the risk of alcohol–drug interactions and adverse outcomes. Biological sex differences may further influence these effects. This study aimed to assess sex-related differences in medication use, comorbidities, and hepatic [...] Read more.
Background/Objectives: Alcohol consumption and medication use have increased among older population, potentially increasing the risk of alcohol–drug interactions and adverse outcomes. Biological sex differences may further influence these effects. This study aimed to assess sex-related differences in medication use, comorbidities, and hepatic biomarkers among older adults with risky alcohol consumption. Methods: A cross-sectional, multicenter study was conducted in 455 adults aged ≥65 years. Sociodemographic and clinical characteristics, medication prescriptions, and hepatic biomarkers were collected. Results: Of the participants, 41% were women, with a mean age of 71 years. The median weekly alcohol consumption was 7 standard drink units. Overall, 90% were taking at least one medication, with antihypertensives being the most prescribed (62%). Significant sex differences were observed (p ≤ 0.01): men showed higher use of antidiabetic drugs (24%), anticoagulants (8%), and nitrates (4%), whereas women more frequently used anxiolytics (35%), non-steroidal anti-inflammatory drugs (22%), and antidepressants (18%). Although risky alcohol consumption was more prevalent among men, women had a higher overall medication use. Significant differences were also observed in hepatic biomarkers, with higher gamma-glutamyl transferase levels and a higher prevalence of elevated FIB-4 values among men (p ≤ 0.01). Conclusions: These findings highlight the importance of routinely assessing alcohol consumption and medication use in older adults and support incorporating a sex-specific perspective into clinical practice and future research. Full article
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