Gene–Diet Interactions and Obesity
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 645
Special Issue Editor
2. Cell Metabolism Unit, IMDEA Food Institute, CEI UAM + CSIC, E28049 Madrid, Spain
Interests: precision nutrition; cancer metabolism; bioactive compounds; lipid metabolism; immunometabolism; meta-inflammation
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to exploring the intricate relationship between gene–diet interactions and obesity, bringing together cutting-edge research that delves into how genetic variations influence dietary responses and contribute to obesity, a global health challenge.
Obesity is a complex, multifactorial condition influenced by both genetic and environmental factors. Genome-wide association studies (GWAS) have identified numerous genetic variants associated with obesity, influencing various biological pathways, including appetite regulation, energy metabolism, and fat storage. Gene–diet interactions occur when the effects of dietary intake on obesity risk are modified by genetic factors. For example, individuals with certain genetic variants may be more susceptible to weight gain when consuming high-fat or high-sugar diets. Conversely, some genetic profiles may confer protection against obesity despite an obesogenic diet.
Epigenetics involves changes in gene expression that do not alter the DNA sequence but can be influenced by environmental factors, including diet. Epigenetic modifications, such as DNA methylation and histone modification, can affect the genes involved in metabolism and fat storage.
Personalized nutrition aims to tailor dietary recommendations by integrating the individual’s genetic profile, nutritional status, and lifestyle aspects to provide more effective strategies for weight management and obesity prevention.
Scope and Topics
Understanding gene–diet interactions is essential for addressing the obesity epidemic. By considering genetic predispositions and dietary factors, researchers and healthcare providers can develop more effective personalized strategies for preventing and managing obesity.
We invite researchers to submit original research articles, reviews, and short communications that address, but are not limited to, the following topics:
- Genetic Predisposition to Obesity: Studies on how specific genetic variants affect susceptibility to obesity.
- Nutrigenomics: Research on how diet influences gene expression related to obesity.
- Epigenetics and Obesity: Investigations into how dietary factors can cause epigenetic changes that impact obesity.
- Personalized Nutrition: Development of dietary recommendations based on genetic profiles to prevent or manage obesity.
Mechanistic Insights: Experimental studies elucidating the biological pathways at the molecular and physiologic level through which diet and genes interact to influence obesity.
Dr. Marta Gómez de Cedrón
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genetic predisposition to obesity
- nutrigenomics
- epigenetics
- precision nutrition
- molecular insights in gene–diet interactions influencing obesity
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