Metabolism of Bioactive Lipids: Molecular Mechanisms in Brain Health, Disease and Clinical Applications

Dear Colleagues,

Bioactive lipids, as essential components in human diet, play a paramount role in human health and wellbeing. In addition to being a source of energy and fatty acids for the synthesis of complex lipids, food bioactive lipid molecules play vital roles in many physiological regulatory processes, such as structure, function, synthesis, restoration, and transportation.

The brain, in particular, is highly susceptible to bioactive nutritional lipids released from processes that range from intrauterine development to aging. So, the quality of bioactive lipids in nutrients can strongly impact brain composition, structure, as well as function and gene expression.

A scientific basis and rational understanding the impact of bioactive lipids on brain is essential to sustaining health and to proposing effective dietary strategies for the prevention of intrauterine nutritional lipid deficiencies leading to attention difficulties, neurobehavioral issues, cerebral palsy, epilepsy, and other cognitive and psychiatric disorders in growing children. Emerging knowledge, similarly, supports preventive and/or adjunctive treatment of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and frontotemporal lobar dementia FTD, and other various brain ailments in the aging population.

The planned Special Issue of Nutrients, entitled “Metabolism of Bioactive Lipids: Molecular Mechanisms in Brain Health, Disease and Clinical Applications”, will include original studies and review articles focusing on: the impact of bioactive lipids and products enriched with them; on human brain metabolism and molecular mechanisms of action; and methods for the prevention of brain disease, with clinical applications throughout the lifespan.

Prof. Dr. Alicia I. Leikin-Frenkel
Guest Editor

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• bioactive
• fatty acids
• phospholipids
• hormones
• brain
• metabolism
• molecular mechanism
• brain health
• clinical applications