nutrients-logo

Journal Browser

Journal Browser

Exercise, Diet, and Mitochondria

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (25 August 2025) | Viewed by 2317

Special Issue Editor


E-Mail Website
Guest Editor
Institute of Sports Sciences, University of Taipei, Taipei City 111, Taiwan
Interests: human performance and sports nutrition; human metabolism and aging

Special Issue Information

Dear Colleagues,

Mitochondria are considered prokaryotes that are symbiotic to eukaryotic cells. They age quickly, within weeks. Unhealthy and aged mitochondria cause cellular dysfunction, inducing immune attack and elevating inflammation in tissues. Exercise is a natural challenge that eliminates weak mitochondria through mitophagy and inducing mitochondrial biogenesis. The influence of diet on this process is a key topic in human health. 

Our aim for this Special Issue is to gather new findings on how exercise and dietary interventions influence mitochondrial health, to expand on the current knowledge in this field.

Prof. Dr. Chia-Hua Kuo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mitochondria
  • exercise
  • nutrition
  • supplements
  • mitophagy
  • biogenesis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

38 pages, 2046 KB  
Review
Effects of Diet and Exercise on Mitochondrial Health in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Role of Ceramides
by Jonas M. McCaffrey and Jamal A. Ibdah
Nutrients 2025, 17(18), 2972; https://doi.org/10.3390/nu17182972 - 16 Sep 2025
Viewed by 1902
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts nearly a quarter of the world’s population and encompasses a range of disease states, from simple steatosis to more advanced stages like metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. A key driver of disease progression is [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts nearly a quarter of the world’s population and encompasses a range of disease states, from simple steatosis to more advanced stages like metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. A key driver of disease progression is mitochondrial dysfunction, characterized by impaired fatty acid oxidation and an overall decline in mitochondrial health. Emerging evidence has implicated ceramides—bioactive sphingolipids that serve roles in apoptotic pathways and as signals of nutrient excess—as important contributors to this dysfunction. Ceramide accumulation within mitochondria mirrors impairments seen in MASLD, specifically elevations in oxidative stress, disrupted fatty acid oxidation, and impaired mitochondrial dynamics. Ceramides may serve as an important molecular link between nutrient overload and mitochondrial dysfunction in the pathogenesis of MASLD. Given the limited availability of effective pharmacologic therapies for MASLD, lifestyle interventions like dietary modification and physical activity remain the cornerstone of disease management worldwide. In this review, we provide an overview of the current understanding of the role of ceramides in mediating the effects of diet and exercise on MASLD through their influence on mitochondrial health. Full article
(This article belongs to the Special Issue Exercise, Diet, and Mitochondria)
Show Figures

Figure 1

Back to TopTop