LC N-3 PUFAs, Vascular Inflammation, and Oxidative Stress

Dear Colleagues,

Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory and antioxidant activities. These effects are attributed in part to suppression of immune cell function. In the in vitro setting, LC n-3 PUFAs have been found to inhibit secretion of pro-inflammatory cytokines from human cultured macrophages after their exposure to a pro-inflammatory stimulus such as lipopolysaccharide. In animal models of cardiovascular disease, LC n-3 PUFAs suppressed activity of the pro-oxidant enzyme, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, to limit cellular formation of reactive oxygen species. However, the extent to which LC n-3 PUFAs attenuate the progression of chronic vascular disease by attenuating inflammation and oxidative stress is yet to be fully resolved. This Special Issue invites reviews, cell-based and animal studies, and clinical trials that provide improved understanding of the anti-inflammatory and antioxidant potential of LC n-3 PUFAs for attenuation of vascular disease. Papers should consider factors that may influence outcomes, including patient profile (for clinical trials), fatty acid dose, type and formulation and duration of treatment.

Assoc. Prof. Fraser Russell
Guest Editor

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