Special Issue "LC N-3 PUFAs, Vascular Inflammation, and Oxidative Stress"
Deadline for manuscript submissions: closed (31 December 2020).
Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory and antioxidant activities. These effects are attributed in part to suppression of immune cell function. In the in vitro setting, LC n-3 PUFAs have been found to inhibit secretion of pro-inflammatory cytokines from human cultured macrophages after their exposure to a pro-inflammatory stimulus such as lipopolysaccharide. In animal models of cardiovascular disease, LC n-3 PUFAs suppressed activity of the pro-oxidant enzyme, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, to limit cellular formation of reactive oxygen species. However, the extent to which LC n-3 PUFAs attenuate the progression of chronic vascular disease by attenuating inflammation and oxidative stress is yet to be fully resolved. This Special Issue invites reviews, cell-based and animal studies, and clinical trials that provide improved understanding of the anti-inflammatory and antioxidant potential of LC n-3 PUFAs for attenuation of vascular disease. Papers should consider factors that may influence outcomes, including patient profile (for clinical trials), fatty acid dose, type and formulation and duration of treatment.
Assoc. Prof. Fraser Russell
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Long chain omega-3 polyunsaturated fatty acids
- Dietary fish
- Oxidative stress
- Nutrient deprivation
- Health benefits
- Immune cell response
- n-3:n-6 PUFA ratio
- Pre-clinical trials
- Clinical trials