Exercise and Nutrition for Older People

Dear Colleagues,

As predicted, the future growth of the older population is inevitable, and, therefore, aiming to reduce age-related comorbidities and maintain the quality of life of older adults (healthspan) have become higher priorities than efforts to simply extend the length of life. Additionally, improving the healthspan will reduce the burden on healthcare systems.

Exercise training is one of the most effective and sustainable lifestyle interventions in preventing the development of age-related comorbidities and premature death as well as improving outcomes in comorbid conditions. Over the last decades we have substantially improved our understanding of the basic biology of aging and the mechanisms of age-related comorbidities, such as the influence of low-grade chronic inflammation and oxidative stress; however, the precise mechanisms of adaptation to exercise training and the heterogeneity of the responsiveness to exercise training in older adults are poorly understood. Additionally, proper nutrition and the supplementation of deficient nutritional compounds may optimize the response to exercise training. Therefore, we need translational investigations to better understand the systemic response to exercise, cross-talk between the organs, and the role of nutrients during the adaptation process. This will help optimize exercise training interventions to be more successfully implemented in clinical practice and the community in order to prevent age-related comorbidities and premature death, with an ultimate goal of improving the healthspan. For this Special Issue, we are inviting a wide range of relevant research, spanning from basic to clinical sciences, including original research, systematic reviews, and meta-analyses covering the following topics, among others:

• Inter-organ communication during adaptation to exercise training, such as studies on the interactions between the microbiome and other organs in normal aging or aging-related conditions.
• Barriers in adaptation to exercise training due to disparities.
• Observational studies or clinical trials on the use of pharmacological, nutraceutical, lifestyle, or other interventions to optimize adaptation to exercise training to improve the healthy aging and quality of life of older adults.
• Use of sophisticated biological techniques, e.g., deep sequencing, on human specimens to generate new evidence in translational research on adaptation to exercise training in older adults.

Dr. Robert T. Mankowski
Guest Editor

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