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Enteral Nutrition—Current Insights and Future Direction

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 June 2026 | Viewed by 1615

Special Issue Editors


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Guest Editor
Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA
Interests: clinical nutrition; enteral nutrition; peptide-based formula; enteral therapies; microbiome; body composition; enteral access; enteral feeding systems; enteral tubes; translational nutrition research; obesity; nutrition care

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Guest Editor
Department of Family Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Interests: enteral nutrition; parenteral nutrition; nutrition support; malnutrition; enteral formulations

Special Issue Information

Dear Colleagues,

Enteral nutrition (EN) is an essential aspect of clinical nutrition, especially for patients who cannot fulfill their nutritional needs through regular eating. As advances in nutritional science and technology progress, our comprehension of EN and its effects on patient outcomes have expanded considerably. This issue, titled “Enteral Nutrition—Current Insights and Future Direction”, aims to shed light on recent research, clinical applications, and creative methods in enteral nutrition while tackling upcoming challenges.

In examining the current state of enteral nutrition, we will cover key topics, including the creation of newer enteral formulations, improvements in access devices, and the influence of nutrition on the microbiome and body composition. The rising awareness of malnutrition as a critical factor contributing to morbidity and mortality across various medical scenarios highlights the necessity for thorough nutritional support. This issue will emphasize the significance of customized enteral feeding plans, particularly for vulnerable groups like the elderly, critically ill patients, and individuals with chronic gastrointestinal conditions.

Additionally, we aim to connect translational nutrition research with clinical practice. By offering insights into existing evidence-based guidelines and exploring future directions, we hope to encourage dialog among researchers, clinicians, and healthcare professionals about emerging themes in the field.

In summary, this Special Issue is designed not only to share innovative research but also to stimulate meaningful discussion regarding the future of enteral nutrition. Together, we can deepen our knowledge and application of EN in clinical settings, ultimately enhancing patient outcomes and overall quality of life.

Dr. Osman Mohamed Elfadil
Dr. Jithinraj Edakkanambeth Varayil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • enteral nutrition
  • tube feeding
  • malnutrition
  • enteral formula
  • feeding systems
  • bioimpedance analysis
  • gut microbiota
  • microbiome
  • critical care
  • home enteral nutrition
  • nutrition care
  • pediatric nutrition
  • enteral access
  • feeding tubes
  • nutrition support

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Published Papers (1 paper)

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Research

11 pages, 211 KB  
Article
Implementation of an Electronic Medical Record-Embedded Refeeding Risk Order Set and Its Impact on Refeeding Syndrome Among Adults Receiving Enteral Nutrition: A Retrospective Cohort Study in an Inpatient Hospital Setting
by Emma Peterson, Audrey Arnold, Kristen Payzant, Leslie Wills, Mariah Jackson, Corri Hanson, Megan Timmerman, Rachel Lietka, Kaiti George and Jana Ponce
Nutrients 2026, 18(2), 226; https://doi.org/10.3390/nu18020226 - 11 Jan 2026
Viewed by 630
Abstract
Background/Objectives: Refeeding syndrome (RFS) is challenging to prevent and manage in hospitalized patients receiving enteral nutrition (EN). Nebraska Medicine implemented an Electronic Medical Record (EMR) Refeeding Risk Order Set (RROS) to standardize prevention measures, including structured electrolyte monitoring, thiamine supplementation, and conservative EN [...] Read more.
Background/Objectives: Refeeding syndrome (RFS) is challenging to prevent and manage in hospitalized patients receiving enteral nutrition (EN). Nebraska Medicine implemented an Electronic Medical Record (EMR) Refeeding Risk Order Set (RROS) to standardize prevention measures, including structured electrolyte monitoring, thiamine supplementation, and conservative EN initiation. This study evaluated whether RROS implementation reduced RFS occurrence or severity and assessed its operational impact. Methods: In this retrospective cohort study, adults receiving EN before and after RROS implementation were compared. Primary outcomes were RFS occurrence and severity; secondary outcomes included EN initiation and advancement rates, electrolyte trends, lab frequency, and electrolyte repletion. Results: RFS occurrence did not differ significantly between groups (92.3% vs. 91.3%, p = 0.694), nor did severity (p = 0.535). The post-RROS group received more electrolyte boluses on EN Day 0 (p = 0.027) and had a lower EN starting rate (15.7 vs. 18.3 mL/h, p = 0.045). Conclusions: Although the RROS did not reduce RFS occurrence or severity, integrating American Society for Parenteral and Enteral Nutrition (ASPEN)-based guidance into the EMR was highly feasible and adopted immediately. Automating electrolyte monitoring, micronutrient supplementation, and conservative feeding initiation reduces the risk of errors and promotes consistent care. These benefits improve workflow efficiency and support providers during high census periods, limited staffing, or when experience varies. Future research should explore combining EMR tools with predictive analytics to optimize early risk identification and individualized management. Full article
(This article belongs to the Special Issue Enteral Nutrition—Current Insights and Future Direction)
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