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Nutrients
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The Role of Vitamin D in Inflammatory Diseases
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The Role of Vitamin D in Inflammatory Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 1061

Special Issue Editor

Dr. Michael F. Holick

grade E-Mail Website
Guest Editor
School of Medicine, Boston University, Boston, MA, USA
Interests: vitamin D; immune function; metabolic bone disease; Ehlers Danlos syndrome; vitamin D metabolites and biologic functions; approaches for treating and preventing vitamin D deficiency; photobiology of vitamin D
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vitamin D is well known for its importance for the maintenance of skeletal health. Over the past several decades, we have recognized that vitamin D has a multitude of other biologic functions and that vitamin D deficiency has been related to a wide variety of acute and chronic illnesses. For the past 50 years in vitro, in vivo, and association studies and clinical trials have revealed the important role that vitamin D plays in maintaining immune health and reducing inflammatory diseases by influencing innate and adaptive immunity. The goal of this special edition is to invite authors to submit manuscripts that relate to how vitamin D mechanistically is able to promote anti-inflammatory activity as well as report on associations and clinical trials that have demonstrated vitamin D’s anti-inflammatory effects for acute and chronic illnesses. Since inflammation has been implicated in autoimmune disorders, cardiovascular disease, gastrointestinal disorders, lung diseases, mental illness, metabolic diseases including type 2 diabetes, neurodegenerative diseases, and some cancers, the authors will have wide latitude regarding the topic of their submission as it relates to the theme of this special edition, the anti-inflammatory activity of vitamin D.

Dr. Michael F. Holick
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D
  • 25-hydroxyvitamin D
  • 1,25-dihydroxyvitamin D
  • inflammation
  • anti-inflammatory activity
  • inflammatory diseases
  • acquired and innate immunity
  • autoimmune disorders
  • type 2 diabetes
  • cardiovascular disease
  • neuro degenerative diseases
  • infectious diseases
  • inflammatory skin disorders
  • cancer

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Published Papers (1 paper)

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Research

11 pages, 1628 KiB  
Article
Vitamin D3, 25-Hydroxyvitamin D3, and 1,25-Dihydroxyvitamin D3 Uptake in Cultured Human Mature Adipocytes
by Nazlı Uçar, Richard. T. Pickering, Peter M. Mueller, Jude T. Deeney, María Morales Suárez-Varela, José Miguel Soriano and Michael F. Holick
Nutrients 2025, 17(13), 2107; https://doi.org/10.3390/nu17132107 - 25 Jun 2025
Viewed by 945
Abstract
Background/Objectives: Vitamin D3 is predominantly sequestered in adipose tissue, where it is slowly mobilized under conditions of deficiency in vivo. However, the kinetics of its uptake, release, and interaction with its major metabolites, 25(OH)D3 and 1,25(OH)2D3, remain [...] Read more.
Background/Objectives: Vitamin D3 is predominantly sequestered in adipose tissue, where it is slowly mobilized under conditions of deficiency in vivo. However, the kinetics of its uptake, release, and interaction with its major metabolites, 25(OH)D3 and 1,25(OH)2D3, remain poorly understood. Given the close relationship between obesity, low-grade chronic inflammation, and disrupted vitamin D metabolism, a clearer understanding of these dynamics in adipocytes is essential. Thus, we sought to characterize time-dependent uptake and metabolites in differentiated human adipocytes. Methods: Human pre-adipocytes were differentiated in vitro and exposed to either vitamin D3 and 1,25(OH)2D3 or the combination of vitamin D3, 25(OH)D3 and 1,25(OH)2D3. Intracellular concentrations were quantified through HPLC at various time points. A separate efflux experiment assessed vitamin D3 release under basal and isoproterenol-stimulated conditions using 3H-vitamin D3 and scintillation counting. Results: Vitamin D3 uptake showed a gradual and sustained increase over 96 h, suggesting ongoing accumulation within lipid-rich compartments. In contrast, 25(OH)D3 and 1,25(OH)2D3 peaked rapidly within the first hour and declined sharply. Isoproterenol stimulation significantly enhanced vitamin D3 release into the extracellular medium from the adipocytes, indicating increased efflux during lipolytic activation. Conclusions: Adipocytes selectively retain vitamin D3 while rapidly clearing its hydroxylated forms. These findings highlight the distinct intracellular handling of vitamin D metabolites and suggest that tailored supplementation strategies—particularly in individuals with excess adiposity—may improve bioavailability and metabolic efficacy. Full article
(This article belongs to the Special Issue The Role of Vitamin D in Inflammatory Diseases)
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