Effects of Lactoferrin Supplementation on Inflammation, Immune Function and Prevention of Respiratory Infections

Dear Colleagues,

Lactoferrin (LF) is a versatile glycoprotein naturally found in human milk (HM) and other secretions. Known for its antimicrobial, immunomodulatory and anti-inflammatory properties, it plays a crucial role in supporting the immune system, promoting gut maturation and protecting neonates—especially preterm infants—against severe infections like necrotizing enterocolitis (NEC) and late-onset sepsis (LOS). These benefits arise from its ability to chelate iron, limiting its availability to pathogens while enhancing host defenses and microbiota diversity.

Recent studies highlight lactoferrin’s antiviral effects, including its role in inhibiting viral entry during the SARS-CoV-2 pandemic and its capacity to modulate inflammation by regulating cytokine production and suppressing pro-inflammatory mediators.

Despite promising results, questions remain about the optimal dosage, timing of administration, usage together with probiotics or other drugs, and long-term safety. Further exploration is needed to establish guidelines for its routine use in clinical and preventive settings.

This Special Issue invites research on lactoferrin’s mechanisms, clinical applications, and potential to prevent infections and inflammation. We welcome original research, reviews and clinical studies exploring its nutritional and therapeutic benefits in diverse populations.

Prof. Dr. Paolo Manzoni
Guest Editor

Dr. Alessandro Messina
Dr. Cecilia Nobili
Guest Editor Assistants

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