Special Issue "Inorganic Nitrate/Nitrite in Human Health and Disease"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 September 2018)
It is now well established that the human body uses exogenous nitrate/nitrite to synthesise the important messenger molecule, nitric oxide (NO) via the nitrate-nitrite-NO pathway. This is especially important in NO-depletion states, where exogenous nitrate/nitrite may be required in greater amounts to maintain health and prevent disease. Given that nitric oxide possesses many organ protective properties it stands to reason that sufficient NO derived from dietary or non-dietary nitrate sources may offer protection against a number of chronic diseases linked to NO depletion (e.g., cardiovascular disease, metabolic disease, respiratory disease). In the last decade there has been a surge in the number of studies examining the effects of nitrate/nitrite on cardiovascular risk factors, however limited studies have examined the association with hard cardiovascular disease endpoints. Furthermore, few studies have examined the effects of long term nitrate intake and cardiovascular disease. Moreover, an even smaller number of studies have examined any association with other diseases, such as metabolic and respiratory disease.
The purpose of this Special Issue, "Inorganic Nitrate/Nitrite in Human Health and Disease" is three-fold: 1) to address the lack of epidemiological research, in particular, longitudinal analyses, examining the relationship between dietary nitrate/nitrate intake and chronic disease, 2) to address the lack of experimental research in humans between dietary or non-dietary nitrate/nitrate intake and chronic disease risk factors (e.g., blood pressure, blood lipids, endothelial function, arterial stiffness, platelet function, inflammatory markers, fasting serum glucose), and 3) to address the lack of human experimental research examining dietary or non-dietary nitrate/nitrate intake interventions for primary or secondary prevention of chronic disease.
Assoc. Prof. Mark McEvoyGuest Editor
Manuscript Submission Information
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- Inorganic nitrate/nitrite
- Cardiovascular disease
- Metabolic disease
- Respiratory disease
- Depressive illness
- Blood pressure
- Endothelial function
- Arterial stiffness
- Platelet function
- Blood lipids
- Markers of glycaemic control