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Nutrients
Special Issues
Nutrition and Nutritional Intervention in Chronic Diseases (2nd Edition)
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Nutrition and Nutritional Intervention in Chronic Diseases (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 3849

Special Issue Editors

Prof. Dr. Artur Mazur

E-Mail Website
Guest Editor
Institute of Medical Sciences, Medical College, University of Rzeszów, 35-310 Rzeszów, Poland
Interests: children; pediatric endocrinology; childhood obesity; inflammatory syndrome; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals
Dr. Paulina Frączek

E-Mail Website
Guest Editor
Faculty of Medicine, Department of Human Immunology, University of Rzeszów, 35-310 Rzeszów, Poland
Interests: pediatrics; immunology; autoimmunity; autoimmune disorders; human immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition is an essential issue at every age. During the past decade, rapid expansion in a number of relevant scientific fields and, in particular, in the amount of population-based epidemiological evidence has helped to clarify the role of diet in the prevention, treatment, and control of morbidity, as well as premature mortality as a result of chronic diseases. Some of the specific dietary components that increase the probability of occurrence of these diseases in individuals, as well as interventions used to modify their impact, have also been identified.

This Special Issue will include manuscripts that focus on nutrition, diet, nutritional treatment, and/or weight status in relation to chronic disease prevention, control, and symptom management. The presented materials are the result of the international scientific cooperation of experts specializing in these issues. The content may be useful to clinical practitioners and inspire further innovative research.

Prof. Dr. Artur Mazur
Dr. Paulina Frączek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional status
  • chronic diseases
  • diet
  • children
  • symptom management

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Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 245 KiB  
Article
The Rising Burden of Childhood Obesity: Prevention Should Start in Primary School
by Debora Porri, Malgorzata Wasniewska, Giovanni Luppino, Letteria Anna Morabito, Elisa La Rosa, Giorgia Pepe, Domenico Corica, Mariella Valenzise, Maria Francesca Messina, Giuseppina Zirilli, Alessandra Li Pomi, Aurora Lanzafame, Angela Alibrandi and Tommaso Aversa
Nutrients 2025, 17(4), 650; https://doi.org/10.3390/nu17040650 - 11 Feb 2025
Cited by 1 | Viewed by 1520
Abstract
Background: The increasing rates of childhood obesity (CO) are an ongoing problem. We focused on the adherence to the Mediterranean diet (MD), physical activity, and sleep habits of preschool children in order to investigate the relationship between lifestyle habits and health outcomes through [...] Read more.
Background: The increasing rates of childhood obesity (CO) are an ongoing problem. We focused on the adherence to the Mediterranean diet (MD), physical activity, and sleep habits of preschool children in order to investigate the relationship between lifestyle habits and health outcomes through parental perception. Methods: In the context of “EpPOI: Education to prevent CO”, we investigated physical activity (PA) and sleep hygiene using an online survey for caregivers. Parents also completed the Mediterranean Diet Quality Index for children and adolescents (Kid-Med) questionnaire. Results: A total of 5.3% of the interviewees achieved a score indicating an adequate adherence to the MD. Additionally, 50.5% of children ate sweets every day, and 80% skipped breakfast. We also found that the parents’ perceptions of their children’s PA were a predictor of MD adherence, and PA was also positively correlated with fruit consumption [p < 0.034], vegetable consumption [p < 0.015], and fish consumption [p < 0.005]. Conclusions: Parents seem to be oriented towards a healthy lifestyle, but the children’s level of adherence to the Mediterranean diet is poor. CO prevention requires a synergic effort that includes an adherence to healthy eating patterns such as the MD and a greater awareness of parents on the importance of adopting a healthy lifestyle at an early age. Full article
(This article belongs to the Special Issue Nutrition and Nutritional Intervention in Chronic Diseases (2nd Edition))
18 pages, 2300 KiB  
Article
A Sustained-Release Butyrate Tablet Suppresses Ex Vivo T Helper Cell Activation of Osteoarthritis Patients in a Double-Blind Placebo-Controlled Randomized Trial
by Sandra G. P. J. Korsten, Merel Hartog, Alinda J. Berends, Marije I. Koenders, Calin D. Popa, Herman Vromans, Johan Garssen, Cornelia H. M. van de Ende, Jan P. W. Vermeiden and Linette E. M. Willemsen
Nutrients 2024, 16(19), 3384; https://doi.org/10.3390/nu16193384 - 4 Oct 2024
Cited by 2 | Viewed by 1843
Abstract
Degenerative joint disease osteoarthritis (OA) is characterized by the degeneration of cartilage, synovial inflammation and low-grade systemic inflammation in association with microbial dysbiosis and intestinal barrier defects. Butyrate is known for its anti-inflammatory and barrier protective effects and might benefit OA patients. In [...] Read more.
Degenerative joint disease osteoarthritis (OA) is characterized by the degeneration of cartilage, synovial inflammation and low-grade systemic inflammation in association with microbial dysbiosis and intestinal barrier defects. Butyrate is known for its anti-inflammatory and barrier protective effects and might benefit OA patients. In a double-blind placebo-controlled randomized trial, the effects of four to five weeks of oral treatment with sustained-release (SR) butyrate tablets (600 mg/day) on systemic inflammation and immune function were studied in hand OA patients. Serum markers for systemic inflammation and lipopolysaccharide (LPS) leakage were measured and ex vivo stimulation of whole blood or peripheral blood mononuclear cells (PBMCs) was performed at baseline and after treatment. Butyrate treatment did not affect the serum markers nor the cytokine release of ex vivo LPS-stimulated whole blood or PBMCs nor the phenotype of restimulated monocytes. By contrast, butyrate treatment reduced the percentage of activated T helper (Th) cells and the Th17/Treg ratio in αCD3/CD28-activated PBMCs, though cytokine release upon stimulation remained unaffected. Nevertheless, the percentage of CD4+IL9+ cells was reduced by butyrate as compared to the placebo. In both groups, the frequency of Th1, Treg, Th17, activated Th17, CD4+IFNγ+ and CD4+TNFα+ cells was reduced. This study shows a proof of principle of some immunomodulatory effects using a SR butyrate treatment in hand OA patients. The inflammatory phenotype of Th cells was reduced, as indicated by a reduced percentage of Th9 cells, activated Th cells and improved Th17/Treg balance in ex vivo αCD3/CD28-activated PBMCs. Future studies are warranted to further optimize the butyrate dose regime to ameliorate inflammation in OA patients. Full article
(This article belongs to the Special Issue Nutrition and Nutritional Intervention in Chronic Diseases (2nd Edition))
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