From Population to Precision: Nutritional Approaches in Metabolic Dysfunction-Associated Steatotic Liver Disease
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".
Deadline for manuscript submissions: 15 January 2026 | Viewed by 10
Special Issue Editors
2. Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Interests: population genetics; MASLD; disease progression; cardiometabolic diseases; precision nutrition; real-world evidence
Special Issues, Collections and Topics in MDPI journals
2. Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Interests: genetics; liver metabolism; MASLD; cardiometabolic disease; precision nutrition; multi-omics research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The liver is central to metabolic regulation, coordinating nutrient processing and energy distribution in response to dietary inputs and energetic demands, thereby playing a vital role in maintaining whole-body metabolic homeostasis. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as NAFLD, is the most common chronic liver condition globally, driven largely by dietary habits, sedentary lifestyles, and the rising prevalence of obesity and type 2 diabetes. Nutrition is pivotal in both the pathogenesis and management of MASLD, influencing hepatic fat accumulation, insulin sensitivity, inflammation, and fibrogenesis. Evidence increasingly supports the role of dietary interventions in influencing the progression of MASLD, particularly those that promote weight loss, improve insulin signaling, and reduce hepatic lipotoxicity. A deeper understanding of how individual genetic and metabolic profiles interact with diet offers new opportunities for personalized nutrition therapies.
This Special Issue will feature innovative research on the role of nutrition in MASLD prevention and management, from clinical trials on dietary interventions to mechanistic studies in nutrient–gene interactions, the use of Mendelian randomization (MR) approaches to strengthen causal inference, and advanced omics techniques to inform personalized dietary strategies. Contributions will reflect both well-established and emerging viewpoints on nutritional therapies and dietary guidelines, including differences across populations, genetic backgrounds, and commercial dietary approaches.
You may choose our Joint Special Issue in Livers.
Dr. Marijana Vujkovic
Dr. Kate Townsend Creasy
Guest Editors
Manuscript Submission Information
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Keywords
- nutrigenomics
- liver metabolism
- NAFLD/MASLD
- nutritional intervention
- dietary patterns
- precision nutrition
- Mendelian randomization
- lifestyle modification
- personalized dietary strategies
- liver disease prevention
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