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Nutrients
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Diet Management in Renal Diseases
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Diet Management in Renal Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 June 2024) | Viewed by 5450

Special Issue Editors

Dr. Irene Capelli

E-Mail Website
Guest Editor
1. Nephrology, Dialysis and Renal Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
2. Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
Interests: chronic kidney injury; rare diseases; diabetes; renal injury biomarkers; diet in the management of CKD
Dr. Carlo Alfieri

E-Mail Website
Guest Editor
1. Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico, Milan, Italy
2. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Interests: renal transplantation; chronic kidney disease; mineral bone disorders in CKD and renal transplanted patients; markers of CKD progression; diet in the management of CKD
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic kidney disease one of the leading causes of morbidity and mortality worldwide. Diet has always played a fundamental role in the conservative management of chronic kidney disease, with the aim of optimizing the impact of metabolic complications and slowing down the progression of the disease.

The nutritional approach is currently highly personalized, particularly in relation to the stage of chronic kidney disease and the type of natural or artificial replacement therapy. Dietary approaches aimed at treating specific pathological conditions of kidney damage are also currently being studied with the aim of integrating the therapies available for some kidney diseases via precise nutritional schemes.

Moreover, recently the presence of new therapeutic possibilities has changed the nutritional approach to patients, with the aim of intervening more in the fields of cardio and nephro-protection, which are the basis of patient survival.

This Special Issue is committed to publishing original research articles on kidney disease nutrition-related intervention, diagnosis and prevention. We aim to provide a comprehensive update on nutrition scientific evidence as a crucial factor in preventing, promoting and treating kidney diseases. Review articles on these topics are welcome.

Dr. Irene Capelli
Dr. Carlo Alfieri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney
  • diet
  • malnutrition
  • CKD
  • nutrition

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Published Papers (2 papers)

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17 pages, 2431 KiB  
Article
Post-Transplant Diabetes Mellitus in Kidney-Transplanted Patients: Related Factors and Impact on Long-Term Outcome
by Carlo Alfieri, Edoardo Campioli, Paolo Fiorina, Emanuela Orsi, Valeria Grancini, Anna Regalia, Mariarosaria Campise, Simona Verdesca, Nicholas Walter Delfrate, Paolo Molinari, Anna Maria Pisacreta, Evaldo Favi, Piergiorgio Messa and Giuseppe Castellano
Nutrients 2024, 16(10), 1520; https://doi.org/10.3390/nu16101520 - 17 May 2024
Cited by 1 | Viewed by 1656
Abstract
This study aimed to investigate the prevalence and determinants of glucose metabolism abnormalities and their impact on long-term clinical outcomes in kidney transplant recipients (KTxps). A retrospective analysis of 832 KTxps (2004–2020) was performed. Patients were assessed at 1 (T1), 6 (T6), and [...] Read more.
This study aimed to investigate the prevalence and determinants of glucose metabolism abnormalities and their impact on long-term clinical outcomes in kidney transplant recipients (KTxps). A retrospective analysis of 832 KTxps (2004–2020) was performed. Patients were assessed at 1 (T1), 6 (T6), and 12 (T12) months post-transplantation and clinically followed for an average of 103 ± 60 months. At T6, 484 patients underwent an oral glucose tolerance test for the diagnosis of alterations in glucose metabolism (AMG+) or post-transplant diabetes mellitus (PTDM+). The prevalence of pre-transplant diabetes was 6.2%, with 22.4% of PTDM+ within the 1st year. Patients with AMG were older and exhibited altered lipid profiles, higher body mass index, and increased inflammatory indices. Age at transplantation, lipid profile, and inflammatory status were significant determinants of PTDM. Graft loss was unaffected by glucose metabolism alterations. Survival analysis demonstrated significantly worse long-term survival for KTxps with diabetes (pre- and PTDM+, p = 0.04). In a comparison of the ND and PTDM+ groups, no significant differences in death with a functioning graft were found. The AMG+ group exhibited worse survival (p < 0.001) than AMG−, even after excluding patients with diabetes mellitus. Future randomized controlled trials are necessary to delve deeper into this subject, specifically examining the effects of new antidiabetic treatments. Full article
(This article belongs to the Special Issue Diet Management in Renal Diseases)
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Review

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22 pages, 704 KiB  
Review
Potential Add-On Benefits of Dietary Intervention in the Treatment of Autosomal Dominant Polycystic Kidney Disease
by Erica Rosati, Giulia Condello, Chiara Tacente, Ilaria Mariani, Valeria Tommolini, Luca Calvaruso, Pierluigi Fulignati, Giuseppe Grandaliano and Francesco Pesce
Nutrients 2024, 16(16), 2582; https://doi.org/10.3390/nu16162582 - 6 Aug 2024
Viewed by 3116
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of renal failure. The pathogenesis of the disease encompasses several pathways and metabolic alterations, including the hyperactivation of mTOR and suppression of AMPK signaling pathways, as well as mitochondrial dysfunction. This [...] Read more.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of renal failure. The pathogenesis of the disease encompasses several pathways and metabolic alterations, including the hyperactivation of mTOR and suppression of AMPK signaling pathways, as well as mitochondrial dysfunction. This metabolic reprogramming makes epithelial cyst-lining cells highly dependent on glucose for energy and unable to oxidize fatty acids. Evidence suggests that high-carbohydrate diets may worsen the progression of ADPKD, providing the rationale for treating ADPKD patients with calorie restriction and, in particular, with ketogenic dietary interventions, already used for other purposes such as in overweight/obese patients or in the treatment of refractory epilepsy in children. Preclinical studies have demonstrated that calorie restriction may prevent and/or slow disease progression by inducing ketosis, particularly through increased beta-hydroxybutyrate (BHB) levels, which may modulate the metabolic signaling pathways altered in ADKPK. In these patients, although limited, ketogenic intervention studies have shown promising beneficial effects. However, larger and longer randomized controlled trials are needed to confirm their tolerability and safety in long-term maintenance and their additive role in the therapy of polycystic kidney disease. Full article
(This article belongs to the Special Issue Diet Management in Renal Diseases)
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