Diet and Lipid Metabolism in Steatotic Liver Disease

Dear Colleagues,

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the most common cause of chronic liver disease in the world. MASLD represents a spectrum of liver-related conditions, including steatosis, Metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma.

A number of dietary components have been implicated in MASLD development and progression, namely saturated fat and free sugars. These components are thought to influence pathways of hepatic lipid metabolism, such as beta-oxidation and de novo lipogenesis, ultimately leading to an imbalance between lipid input and disposal pathways in the liver and fat accumulation. Additionally, this accumulation of lipids in hepatocytes is thought to lead to the activation of inflammatory pathways, ultimately resulting in hepatocellular damage. However, there is heterogeneity in MASLD pathogenesis, and the dietary responses in hepatic lipid metabolism in varied populations are unclear. Furthermore, as lifestyle interventions such as diet modification represent the cornerstone management strategy for MASLD, establishing optimal dietary patterns and strategies for the prevention and treatment of MASLD is key.

The aims of this Special Issue are, therefore, to provide key research advancements in regards the interaction between diet and MASLD to aid in the identification of strategies to prevent or reverse hepatic fat accumulation.

Dr. Siôn Parry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.