nutrients-logo

Journal Browser

Journal Browser

Nutrition and Chronic Pain: Clinical and Population-Based Evidence and Mechanistic Insights

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 October 2026 | Viewed by 800

Special Issue Editor


E-Mail Website
Guest Editor
Department of Physical Medicine and Rehabilitation, Program on Integrative Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Interests: chronic pain; functional impairment; cognitive impairment; nutrition interventions; mind–body interventions; dietary supplements and other natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pain—defined as pain persisting for at least three months after an injury—poses a major public health challenge. It is associated with substantial healthcare costs and contributes to reduced physical function and diminished quality of life (Elma, 2022). Although the etiology of chronic pain is multifactorial, growing evidence implicates neuroinflammation and maladaptive neuroplastic changes as key mechanisms underlying its persistence (Field, 2021). Pharmacologic treatments, while commonly prescribed, often yield limited symptom relief and can produce significant adverse effects (Qaseem, 2017). Consequently, clinical guidelines increasingly emphasize nonpharmacologic, integrative approaches as first-line management, including dietary interventions, dietary supplements, physical therapy, acupuncture, and mind–body therapies (Qaseem, 2017).

This Special Issue invites contributions that explore integrative approaches for managing chronic pain, with a particular focus on interventions that include a nutritional component or measurement. Submissions may include primary or secondary analyses from clinical trials, observational studies, or mechanistic investigations that elucidate the role of nutrition or dietary supplements within multimodal pain management strategies. We also welcome systematic reviews and meta-analyses that synthesize recent high-quality clinical evidence. Papers that integrate nutritional strategies with other nonpharmacologic modalities are encouraged. Prospective authors are invited to contact the Guest Editors with questions or to discuss the suitability of proposed manuscripts.

Looking forward to chatting with you about potential manuscripts.

  1. Elma, Ö.; Brain, K.; Dong, H.-J. The Importance of Nutrition as a Lifestyle Factor in Chronic Pain Management: A Narrative Review. J. Clin. Med. 2022, 11, 5950. https://doi.org/10.3390/jcm11195950.
  2. Field R, Pourkazemi F, Turton J, Rooney K. Dietary Interventions Are Beneficial for Patients with Chronic Pain: A Systematic Review with Meta-Analysis. Pain Med. 2021, 22(3), 694. https://doi.org/10.1093/pm/pnaa378. PMID: 33202007.
  3. Qaseem A, Wilt TJ, McLean RM, Forciea MA; Clinical Guidelines Committee of the American College of Physicians; Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP, Humphrey LL, Vijan S. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017, 166, 514. https://doi.org/10.7326/M16-2367. PMID: 28192789.

Dr. Keturah R. Faurot
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic pain
  • integrative medicine
  • nutritional interventions
  • nonpharmacologic therapies
  • lifestyle modification
  • dietary supplements

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

25 pages, 1815 KB  
Article
Real-World Before–After Study of Gastrodia elata Blume-Based Nutraceutical Supplementation in Patients with Radiculopathy and Carpal Tunnel Syndrome
by Marco Invernizzi, Lorenzo Lippi, Simone Mulè, Rebecca Galla, Arianna Folli, Domenico Tiso, Francesca Parini and Francesca Uberti
Nutrients 2026, 18(9), 1438; https://doi.org/10.3390/nu18091438 - 30 Apr 2026
Viewed by 503
Abstract
Background/Objectives: Cervical and lumbar radiculopathy and carpal tunnel syndrome (CTS) are common conditions that are associated with persistent pain, functional impairment, and reduced quality of life. Nutraceutical strategies targeting neuroinflammatory and oxidative stress pathways are being investigated as adjunctive approaches in pain [...] Read more.
Background/Objectives: Cervical and lumbar radiculopathy and carpal tunnel syndrome (CTS) are common conditions that are associated with persistent pain, functional impairment, and reduced quality of life. Nutraceutical strategies targeting neuroinflammatory and oxidative stress pathways are being investigated as adjunctive approaches in pain management. This study evaluated the clinical association between supplementation with a Gastrodiae elata Blume-based nutraceutical formulation (Assonal®) and changes in pain intensity, functional outcomes, symptom burden, and quality of life in patients with radiculopathy and CTS. Methods: A single-centre pragmatic before–after clinical study enrolled adults with cervical or lumbar radiculopathy and/or CTS. Participants received Assonal® (two tablets daily) for two months. Pain intensity was assessed using the Numerical Pain Rating Scale (NPRS) and Visual Analogue Scale (VAS). Secondary outcomes included the Back Pain Functional Scale (BPFS), the Boston Carpal Tunnel Questionnaire (BCTQ), the Neuropathic Pain Symptom Inventory (NPSI), the EuroQol-5D-5L (EQ-5D-5L), and the Global Perceived Effect (GPE). Longitudinal within-subject changes were analysed using repeated-measures statistical tests. Results: Thirty-four participants completed the study. The observed pain intensity decreased significantly from baseline to two months (NPRS: 7.2 ± 1.3 to 3.6 ± 1.2; VAS: 7.3 ± 2.1 to 3.3 ± 1.7; p < 0.0001) and functional measures showed improvements across BPFS and BCTQ assessments, accompanied by reductions in symptom burden (NPSI). Quality of life increased significantly (EQ-5D-5L index: 0.49 ± 0.23 to 0.81 ± 0.12; p < 0.0001), and most patients reported perceived clinical improvement. Conclusions: In this exploratory real-world study, Assonal® supplementation was associated with clinically relevant improvements in pain intensity, functional performance, and quality of life in patients with radiculopathy and CTS, suggesting the need for further investigation of these associations in future controlled clinical studies. Full article
Show Figures

Figure 1

Back to TopTop