Association between Nutritional Status, Obesity and Puberty Timing
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".
Deadline for manuscript submissions: closed (16 October 2023) | Viewed by 3789
Special Issue Editor
2. Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
3. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan
4. Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan
Interests: childhood obesity; childhood atopic diseases; pubertal development; nutrition
Special Issue Information
Dear Colleagues,
In the past two decades, a secular trend of early puberty has been reported globally. Early puberty, such as precocious puberty (PP) in extreme cases, presents as premature activation of the hypothalamic–pituitary–gonadal (HPG) axis, and children experience their sexual maturation before the age of 9 in boys or 8 in girls. To our knowledge, the exact biological pathway of early puberty above the hypothalamus level has not been clearly delineated. Instead, it is supposed to be a multifactorial disorder caused by a complex interaction between genetic, nutritional, environmental, and socio-economic factors. Pubertal timing is sensitive to nutritional regulation. Caloric over-consumption links to the accumulation of body fat, which elevates leptin levels, a signal to the brain to trigger the onset of puberty. Untreated early puberty may result in the paradox of tall stature in childhood but short final adult height, owing to the premature closure of epiphyseal growth plates in long bones; or, it may lead to subsequent cardiometabolic adverse outcomes, including hyperinsulinemia, obesity, type 2 diabetes, hypertension, breast cancer, cardiovascular disease, and all-cause mortality.
In this Special Issue, we will cover clinical, epidemiological, and experimental research investigating the interrelationships between nutritional status, obesity, and puberty timing. We will focus on macro-, micro-, food intake, and dietary patterns causing changes in adiposity growth or pubertal timing. Studies using a multi-omics approach (genomics, metabolomics, microbiomics) are specifically welcomed. In the multi-omics era, it is necessary to examine individual variation in response to a specific diet, as well as how diet influences metabolic regulation in children with early puberty, in order to achieve personalized dietary recommendations.
Dr. Yang-Ching Chen
Guest Editor
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Keywords
- nutrient intake
- childhood obesity
- early puberty
- sexual maturation
- puberty timing
- early menarche
- early voice breaking
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