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Nutrients
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Impact of Optimized Nutritional Strategies on Weight Control
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Impact of Optimized Nutritional Strategies on Weight Control

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 25 October 2025 | Viewed by 526

Special Issue Editor

Dr. Maria Morgan-Bathke

E-Mail Website
Guest Editor
Department of Nutrition and Dietetics, Viterbo University, La Crosse, WI 54601, USA
Interests: obesity and inflammation; insulin signaling; fat metabolism; dietary in-terventions, inflammation and hormones

Special Issue Information

Dear Colleagues,

This Special Issue of Nutrients, entitled “Impact of Optimized Nutritional Strategies on Weight Control”, welcomes the submission of manuscripts that either describe original research or review scientific literature related to weight management. Manuscripts should focus on nutritional strategies for weight maintenance in individuals with overweight or obesity, with special attention on personalization of dietary intervention. Manuscripts that address potential gender- and age-related differences and individual factors that may predict weight maintenance success are especially welcome.

Potential topics may include, but are not limited to, the following:

  • Medical nutrition therapy for adult weight management;
  • Nutrigenomic approach to adult weight management;
  • Macronutrient distribution for adult weight control;
  • Dietary interventions for adult weight control.

Dr. Maria Morgan-Bathke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • weight management
  • nutrigenomics
  • medical nutrition therapy
  • macronutrients
  • dietary interventions

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Published Papers (1 paper)

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Research

10 pages, 847 KiB  
Article
Impact of a 12-Week Hypocaloric Weight Loss Diet with Mixed Tree Nuts vs. Pretzels on Trimethylamine-N-Oxide (TMAO) Levels in Overweight Adults
by Onkei Lei, Jieping Yang, Hannah H. Kang and Zhaoping Li
Nutrients 2025, 17(13), 2137; https://doi.org/10.3390/nu17132137 - 27 Jun 2025
Viewed by 113
Abstract
Trimethylamine N-oxide (TMAO), a gut microbiome metabolite linked to cardiovascular health, can be influenced by dietary factors like choline intake and diet quality. This study compared the effects of mixed tree nuts (MTNs) and pretzels, as part of a 12-week hypocaloric weight loss [...] Read more.
Trimethylamine N-oxide (TMAO), a gut microbiome metabolite linked to cardiovascular health, can be influenced by dietary factors like choline intake and diet quality. This study compared the effects of mixed tree nuts (MTNs) and pretzels, as part of a 12-week hypocaloric weight loss diet, on TMAO levels and identified dietary predictors. Methods: Plasma samples from 95 overweight individuals consuming either 1.5 oz. of mixed tree nuts (MTNs, n = 56) or isocaloric pretzels (n = 39) daily for 12 weeks were analyzed. Nutritional data were collected at baseline and week 12 through dietary recall using the Automated Self-Administered 24 h Dietary Assessment Tool (ASA24), and the overall diet quality was assessed via the Healthy Eating Index (HEI) score. TMAO levels were determined and analyzed using linear mixed-effect models, adjusting for covariates. Wilcoxon signed-rank tests compared baseline and week 12 TMAO and weight. Multiple linear regression identified baseline predictors of TMAO. Results: Baseline demographics, anthropometric measures, HEI scores, and dietary choline intake were similar between the MTN and pretzel groups. A significant positive association was observed between baseline dietary choline and plasma TMAO levels (p = 0.012). The 12-week hypocaloric diet led to significant weight reduction in both groups (p < 0.01), but the magnitude of weight loss did not differ significantly between the MTN (−3.47 lbs) and pretzel (−4.25 lbs) groups (p = 0.18). Plasma TMAO levels decreased significantly in both groups (p < 0.01), but the between-group difference in reduction was not significant. (MTNs: −0.34 vs. pretzels: −0.37; p = 0.43). HEI scores and dietary choline intake remained unchanged, with no significant time–intervention interaction. Participants with low baseline HEI scores (≤53.72) had a more pronounced reduction in TMAO levels in the MTN group compared to the pretzel group (MTN: −0.54 vs. pretzel: −0.23; p = 0.045) over 12 weeks, despite similar weight loss. This difference was not observed in participants with higher HEI scores. Conclusions: The 12-week hypocaloric diet reduced body weight and plasma TMAO levels similarly in both MTN and pretzel groups. Participants with lower dietary quality saw a greater reduction in TMAO levels in the MTN group, suggesting MTNs may better modulate TMAO levels, especially for those with poorer baseline diets. Full article
(This article belongs to the Special Issue Impact of Optimized Nutritional Strategies on Weight Control)
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