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Endocrine Disturbances and Nutritional Therapies

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 1249

Special Issue Editors


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Guest Editor
Department of Medical Biochemistry, Jagiellonian University, Medical College, 7 Kopernika Street, 31-034 Kraków, Poland
Interests: obesity; insulin resistance; type 2 diabetes; endocrine disturbances; adipose tissue; skeletal muscle; oxidative stress

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Guest Editor
Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland
Interests: molecular aspects of natural compound activity, including the regulation of signaling pathways; mechanisms of cytotoxicity of natural compounds; the effects of phytochemicals and pharmaceuticals on mitochondrial process regulation, including the role of the AMPK signaling pathway and autophagy; targeting cell metabolism for novel therapies
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Special Issue Information

Dear Colleagues,

Endocrine disorders, such as obesity, type 2 diabetes mellitus, gestational diabetes mellitus, hypercholesterolemia, metabolic syndrome, polycystic ovary syndrome (PCOS), and thyroid dysfunction—represent some of the most critical global health challenges of the 21st century. These conditions exhibit complex interrelations with nutritional status, energy homeostasis, hormonal regulation, and chronic low-grade inflammation. Nutrition plays a dual role, acting both as an etiological factor in the pathogenesis of these disorders and as a fundamental component in their medical and dietary management.

This Special Issue, “Endocrine Disturbances and Nutritional Therapies”, will comprehensively explore the role of nutritional interventions in modulating endocrine and metabolic dysregulations. A particular emphasis will be placed on macronutrient distribution, comprehensive dietary patterns (such as Mediterranean, low-carbohydrate, plant-based, and ketogenic diets), functional foods, and micronutrient optimization in regulating hormonal balance, glycemic control, lipid metabolism, body composition, and inflammatory markers.

We invite original research articles, systematic reviews, meta-analyses, and epidemiological studies that provide mechanistic insights or robust clinical evidence from medical sciences, molecular biology, clinical nutrition, and public health. Through the incorporation of interdisciplinary data, this Special Issue will advance precise nutritional strategies, including therapeutic diets, for the prevention and treatment of endocrine disorders.

Dr. Patrycja Bronowicka-Adamska
Dr. Małgorzata Tyszka-Czochara
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • type 2 diabetes
  • gestational diabetes
  • insulin resistance
  • hypercholesterolemia
  • dyslipidemia
  • metabolic syndrome
  • PCOS
  • polycystic ovary syndrome
  • thyroid dysfunction
  • hypothyroidism
  • hyperthyroidism

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Published Papers (2 papers)

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Research

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19 pages, 323 KB  
Article
Diet Quality and Nutritional Value in Children and Adolescents with Excess Body Weight and Dyslipidemia Undergoing Low-Glycemic Index or Standard Diet
by Beata Bondyra-Wiśniewska and Anna Harton
Nutrients 2026, 18(3), 448; https://doi.org/10.3390/nu18030448 - 29 Jan 2026
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Abstract
Background/Objectives: The increasing problem of excess body weight and the resulting dyslipidemia among children and adolescents is a serious health challenge that may have long-term consequences. In this context, the search continues for an optimal diet that will support both body weight [...] Read more.
Background/Objectives: The increasing problem of excess body weight and the resulting dyslipidemia among children and adolescents is a serious health challenge that may have long-term consequences. In this context, the search continues for an optimal diet that will support both body weight normalization and improvement in lipid parameters. In the prevention and treatment of cardiovascular diseases and lipid disorders, limiting highly processed foods and replacing them with natural, minimally processed options lower in fat, saturated fatty acids (SFA), cholesterol, sugar, and salt is recommended. This study aimed to assess the quality and nutritional value of the low-glycemic index (LGI) diet and standard (ST) diet. Methods: Both diets were based on the principal recommendation of the Cardiovascular Health Integrated Lifestyle Diet-2 (CHILD-2). The Diet Quality Index (DQI) was used to assess the diet quality. Moreover, the nutritional value of the diet was assessed before and after 8 weeks of intervention. The study included 40 patients aged 8–16 years with excess body weight and dyslipidemia who completed the entire nutritional intervention. Results: This study demonstrated that both LGI and ST diets were effective in improving diet quality. The nutritional intervention led to an almost 2-fold reduction in the mean DQI score in the LGI diet group and almost 1.5-fold reduction in the ST diet group (significant differences between groups). No participants were classified into a lower diet quality category than at baseline. The percentage of participants with minimum moderate diet quality reached 100% in the LGI diet group and 44% in the ST diet group. Changes in nutritional value were similar in the LGI and ST diet groups. Both interventions resulted in a significant increase in protein and fiber consumption, as well as a decrease in cholesterol, SFA, and sodium. A greater improvement in diet quality was significantly associated with lower fat and SFA, as well as higher vitamin C intake, in both groups; specifically, it was also associated with reduced cholesterol and sugar intake in the LGI diet group, and reduced sodium intake in the ST diet group. Conclusions: These results suggest that in the dietary therapy of children and adolescents with excess body weight and dyslipidemia, the quality of the diet is crucial, as it is associated with beneficial changes in nutritional value, which may have a positive impact on patient health. To achieve this, however, constant and consistent cooperation with a dietitian is necessary to help implement appropriate dietary recommendations in practice. Further long-term, larger-scale studies are needed. Full article
(This article belongs to the Special Issue Endocrine Disturbances and Nutritional Therapies)

Review

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19 pages, 1494 KB  
Review
The Ketogenic Diet in Type 2 Diabetes and Obesity: A Narrative Review of Clinical Evidence
by Julia Kilian, Dominika Szlęzak, Malgorzata Tyszka-Czochara, Elżbieta Filipowicz-Popielarska and Patrycja Bronowicka-Adamska
Nutrients 2026, 18(3), 397; https://doi.org/10.3390/nu18030397 - 25 Jan 2026
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Abstract
Type 2 diabetes mellitus (T2DM) and obesity represent a growing global public health challenge, strongly associated with excess body weight, unhealthy dietary habits, and a sedentary lifestyle. The ketogenic diet (KD), characterized by very low carbohydrate intake, moderate protein intake, and high fat [...] Read more.
Type 2 diabetes mellitus (T2DM) and obesity represent a growing global public health challenge, strongly associated with excess body weight, unhealthy dietary habits, and a sedentary lifestyle. The ketogenic diet (KD), characterized by very low carbohydrate intake, moderate protein intake, and high fat consumption, induces a metabolic state known as ketosis, in which the body switches from glucose to fat as its primary energy source. KD has gained increasing interest as a strategy to improve glycemic control, reduce body weight, and improve lipid profiles in individuals with obesity and T2DM. The purpose of this narrative review is to summarize the current scientific evidence on the effects of KD on key metabolic parameters, including blood glucose levels, glycated hemoglobin (HbA1c), body weight, and body composition. The analysis is based on peer-reviewed articles retrieved from PubMed, Embase, and Scopus with particular emphasis on clinical studies that provide robust evidence on the efficacy and safety of KD in the treatment of metabolic disorders. Full article
(This article belongs to the Special Issue Endocrine Disturbances and Nutritional Therapies)
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