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Nutrients
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Diet in the Pathogenesis and Management of Inflammatory Bowel Disease
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Diet in the Pathogenesis and Management of Inflammatory Bowel Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 1428

Special Issue Editors

Dr. Vaios Svolos

E-Mail Website
Guest Editor
1. Lab of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sports Science and Dietetics, University of Thessaly, Trikala, Greece
2 School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Interests: inflammatory bowel disease; crohn’s disease; ulcerative colitis; diet; nutrition; gastroenterology; dietary interventions; microbiome; nutritional therapy; enteral nutrition
Prof. Dr. Andreas Kapsoritakis

E-Mail Website
Co-Guest Editor
Department of Gastroenterology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece
Interests: inflammatory bowel disease; crohn’s disease; ulcerative colitis; gastroenterology
Dr. Konstantinos Argyriou

E-Mail Website
Co-Guest Editor
Department of Gastroenterology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece
Interests: inflammatory bowel disease; crohn’s disease; ulcerative colitis; gastroenterology
Dr. Konstantinos Gkikas

E-Mail Website
Guest Editor Assistant
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Interests: inflammatory bowel disease; crohn’s disease; ulcerative colitis; diet; nutrition; gastroenterology; dietary interventions; microbiome; nutritional therapy; enteral nutrition

Special Issue Information

Dear Colleagues,

Inflammatory bowel disease (IBD) presents a significant global health burden with profound impacts on patient quality of life. While its precise etiology remains multifactorial, emerging evidence highlights the crucial role of diet and nutrition in both IBD onset and progression. Nutrition can modulate gut microbiota, immune responses, and intestinal permeability, thereby influencing disease susceptibility and activity.

This Special Issue invites original research articles and high-quality reviews exploring the relationship between diet, nutrition, and IBD, addressing a wide range of topics, including the following:

  • The influence of dietary patterns, specific nutrients, and food components on IBD onset and progression.
  • The impact of diet on gut microbiota composition and function in IBD.
  • Mechanistic studies on dietary modulation of intestinal inflammation.
  • Evidence-based dietary interventions for IBD management, including exclusion diets and enteral nutrition.
  • The role of food additives, ultra-processed foods, and environmental factors in IBD.
  • Nutritional deficiencies and supplementation strategies in IBD.
  • Patient perspectives on dietary modifications and adherence to dietary therapies.

Our goal is to provide a comprehensive overview of diet, nutrition, and IBD interactions, offering insights into innovative dietary strategies that complement conventional therapeutic approaches for IBD patients. We look forward to receiving your valuable contributions to this Special Issue.

Dr. Vaios Svolos
Prof. Dr. Andreas Kapsoritakis
Dr. Konstantinos Argyriou
Guest Editors

Dr. Konstantinos Gkikas
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease (IBD)
  • Crohn's disease
  • ulcerative colitis
  • dietary interventions
  • microbiome
  • nutritional therapy
  • exclusive enteral nutrition
  • partial enteral nutrition
  • low FODMAP diet
  • Mediterranean diet
  • fiber intake
  • probiotics
  • prebiotics
  • food additives
  • nutritional deficiencies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

23 pages, 261 KiB  
Article
Evaluating the Efficacy of Probiotics on Disease Progression, Quality of Life, and Nutritional Status Among Patients with Crohn’s Disease: A Multicenter, Randomized, Single-Blinded Controlled Trial
by Maha Hoteit, Mohamad Hellani, Mohamad Karaja, Nadeen Zayour, Zahra Sadek, Bilal Hotayt and Mahmoud Hallal
Nutrients 2025, 17(4), 708; https://doi.org/10.3390/nu17040708 - 17 Feb 2025
Viewed by 1173
Abstract
Background: There is growing interest in the role of gut microbiota in the pathophysiology of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD). Probiotics have been proposed as a potential adjunct therapy for these conditions by altering the intestinal environment, although studies on [...] Read more.
Background: There is growing interest in the role of gut microbiota in the pathophysiology of inflammatory bowel diseases (IBDs), including Crohn’s disease (CD). Probiotics have been proposed as a potential adjunct therapy for these conditions by altering the intestinal environment, although studies on their effectiveness have yielded mixed results. Aim: This study aims to evaluate the short-term (2 months) effects of a dietary supplement containing Lactobacilli, Bifidobacteria, and Lactococcus bacillus on disease progression, remission, quality of life, and nutritional intake in Lebanese patients with CD. Method: A multicenter, randomized, single-blind controlled trial was conducted in 2 medical centers in Beirut from 1 April 2024 to 1 August 2024. Recruitment, prescreening, screening, enrollment, and protocol implementation were carried out at both centers. Data were collected from 21 patients with CD, who were randomly assigned to the control group (n = 10) and the intervention group (n = 11). At baseline and after two months, participants underwent clinical assessments, WHOQOL-BREF evaluation, and 24 h dietary recalls. Follow-up visits included surveys on disease progression, quality of life, adherence, and adverse events, along with repeat body composition and anthropometric measurements. Results: Probiotic supplementation over two months did not significantly alter symptoms, flares, or hospitalizations outcomes between the control and intervention groups. However, the intervention group experienced notable increases in body weight (p = 0.01), BMI (p = 0.01), body fat mass (p = 0.04), and arm muscle circumference (p = 0.01). Nutrient intake patterns differed, with the intervention group showing increased consumption of calcium, riboflavin, and folate compared to controls (p = 0.01, p = 0.04, p = 0.013, respectively). Probiotic supplementation led to significant within-group increases in dietary fiber (p = 0.01), total sugar (p = 0.02), and caffeine (p = 0.01) among the intervention participants. Adverse effects in the intervention group were mild, including nausea (18.2%) and abdominal discomfort (9.1%). QOL improved significantly in the intervention group, particularly in physical (p = 0.03), psychological (p = 0.04), and environmental domains (p = 0.003), while the control group exhibited improvements only in psychological health. Conclusions: Overall, the findings suggest that probiotics can enhance body composition, nutrient intake, and certain aspects of QOL among CD patients, despite minimal impact on disease symptoms or dietary patterns. Full article
(This article belongs to the Special Issue Diet in the Pathogenesis and Management of Inflammatory Bowel Disease)
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