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Nutrition and the Gut Microbiome in Infants

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 3989

Special Issue Editor


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Guest Editor
1. EACH (USP Leste) Escola de Artes, Ciências e Humanidades da Universidade de São Paulo, São Paulo 03828-000, SP, Brazil
2. Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo 05508000, SP, Brazil
Interests: human microbiome; infants; breastfeeding; preterm babies; microbe–host interaction

Special Issue Information

Dear Colleagues,

The role of the microbiome in human growth has been clarified in recent years. Any disruption to nutrient absorption, regardless of the quantity or types of food consumed, has the potential to limit or modify normal growth. The intestinal microbiome interacts with the host mucosa, and in doing so, contributes to the development of gut function, stimulates the immune system, contributes to the regulation and maintenance of intestinal barrier function, provides protection against infection, and promotes food tolerance, and consequently, eubiosis status. The intestinal microbiome promotes the digestion and absorption of carbohydrates in the small intestine and colon, where organic carbohydrates are fermented to short-chain fatty acids (SCFA). The dietary provision of macro- and micronutrients impacts the gut microbiome and its metabolic activity. Phytochemicals in plant-based foods may have prebiotic effects on the gut microbiome, especially in dysbiosis. Disruption of this ecosystem may be associated with the pathogenesis of diseases (dysbiosis) and clinical conditions such as nosocomial infection, inflammatory bowel disease (IBD), obesity, autoimmune diseases, and allergies. The aim of this Special Issue is to discuss the role of nutrition in the establishment of the gut microbiome in infants, and its implications in child health and development.

Dr. Carla Romano Taddei
Guest Editor

Manuscript Submission Information

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Keywords

  • gut microbiome
  • nutrition
  • infants
  • development
  • dysbiosis
  • dietary macro- and micronutrients
  • breastmilk
  • probiotics, prebiotics and postbiotics

Published Papers (1 paper)

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Research

19 pages, 2219 KiB  
Article
Early Probiotic Supplementation of Healthy Term Infants with Bifidobacterium longum subsp. infantis M-63 Is Safe and Leads to the Development of Bifidobacterium-Predominant Gut Microbiota: A Double-Blind, Placebo-Controlled Trial
by Akari Hiraku, Setsuko Nakata, Mai Murata, Chendong Xu, Natsumi Mutoh, Satoshi Arai, Toshitaka Odamaki, Noriyuki Iwabuchi, Miyuki Tanaka, Takahisa Tsuno and Masahiko Nakamura
Nutrients 2023, 15(6), 1402; https://doi.org/10.3390/nu15061402 - 14 Mar 2023
Cited by 5 | Viewed by 3738
Abstract
Bifidobacteria are important intestinal bacteria that provide a variety of health benefits in infants. We investigated the efficacy and safety of Bifidobacterium longum subsp. infantis (B. infantis) M-63 in healthy infants in a double-blind, randomized, placebo-controlled trial. Healthy term infants were [...] Read more.
Bifidobacteria are important intestinal bacteria that provide a variety of health benefits in infants. We investigated the efficacy and safety of Bifidobacterium longum subsp. infantis (B. infantis) M-63 in healthy infants in a double-blind, randomized, placebo-controlled trial. Healthy term infants were given B. infantis M-63 (n = 56; 1 × 109 CFU/day) or placebo (n = 54) from postnatal age ≤ 7 days to 3 months. Fecal samples were collected, and fecal microbiota, stool pH, short-chain fatty acids, and immune substances were analyzed. Supplementation with B. infantis M-63 significantly increased the relative abundance of Bifidobacterium compared with the placebo group, with a positive correlation with the frequency of breastfeeding. Supplementation with B. infantis M-63 led to decreased stool pH and increased levels of acetic acid and IgA in the stool at 1 month of age compared with the placebo group. There was a decreased frequency of defecation and watery stools in the probiotic group. No adverse events related to test foods were observed. These results indicate that early supplementation with B. infantis M-63 is well tolerated and contributes to the development of Bifidobacterium-predominant gut microbiota during a critical developmental phase in term infants. Full article
(This article belongs to the Special Issue Nutrition and the Gut Microbiome in Infants)
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