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Nutrigenetics and Nutrigenomics of Inflammatory Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (5 July 2024) | Viewed by 3738

Special Issue Editor


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Guest Editor
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, Greece
Interests: genetics; nutrigenetics; personalized nutrition; artificial intelligence (AI); machine learning (ML); non-communicable diseases (NCDs); obesity; metabolic dysfunction-associated steatotic liver disease (MASLD)
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Special Issue Information

Dear Colleagues,

Inflammatory diseases present a multifactorial nature, characterized by a cascade of events implicating the effect of factors of genetic predisposition and their reciprocal interplay with lifestyle determinants (e.g., diet) on multiple physiological and metabolic mechanisms. Recent advances in the field of nutrigenetics and nutrigenomics highlight the impact of gene–diet interactions in the manifestation and phenotypic severity of inflammatory diseases, as well as the formation of indices related to inflammatory disorders, such as parameters of cardiometabolic profile.

This Special Issue will focus on addressing the effect of the role of nutrigenetics and nutrigenomics on various disorders of inflammatory character. We aim to provide a comprehensive update on recent findings in the field by welcoming articles addressing the influence of gene–diet interactions on metabolic and physiologic pathways pertaining to inflammatory mechanisms and/or their effect on overall health and cardiometabolic status.

Prof. Dr. George Dedoussis
Guest Editor

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Keywords

  • nutrigenetics
  • nutrigenomics
  • gene-diet interactions
  • lifestyle
  • inflammatory diseases
  • inflammation
  • cardiometabolic profile

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Published Papers (1 paper)

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Research

17 pages, 942 KiB  
Article
A Dietary Intervention in Adults with Overweight or Obesity Leads to Weight Loss Irrespective of Macronutrient Composition
by Maria Kafyra, Ioanna Panagiota Kalafati, Garyfallia Stefanou, Georgia Kourlaba, Panagiotis Moulos, Iraklis Varlamis, Andriana C. Kaliora and George V. Dedoussis
Nutrients 2024, 16(17), 2842; https://doi.org/10.3390/nu16172842 - 25 Aug 2024
Cited by 2 | Viewed by 2996
Abstract
Obesity is a critical public health issue, necessitating effective weight loss interventions. While various dietary regimens have been explored, individual responses to interventions often vary. This study involved a 3-month dietary intervention aiming at assessing the role of macronutrient composition and the potential [...] Read more.
Obesity is a critical public health issue, necessitating effective weight loss interventions. While various dietary regimens have been explored, individual responses to interventions often vary. This study involved a 3-month dietary intervention aiming at assessing the role of macronutrient composition and the potential role of genetic predisposition in weight loss among Greek adults. This randomized clinical trial followed the CONSORT principles, recruiting 202 participants overall; 94 received a hypocaloric, high-protein diet and 108 received a high-carbohydrate, hypocaloric diet. Genetic predispositions were assessed through 10 target variants known for their BMI associations. Participants’ weight and BMI values were recorded at baseline and post-intervention (n = 202 at baseline, n = 84 post-intervention) and an imputation method was applied to account for the observed missing values. Participants experienced a statistically significant weight loss across all dietary regimens (p < 0.001). Genetic analyses did not display statistically significant effects on weight loss. No significant differences in weight loss were observed between macronutrient groups, aligning with the POUNDS Lost and DIETFITS studies. This study underscores the importance of dietary interventions for weight loss and the potential contributions of genetic makeup. These findings contribute to obesity management within the Greek population and support the need for further research in personalized interventions. Full article
(This article belongs to the Special Issue Nutrigenetics and Nutrigenomics of Inflammatory Disorders)
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