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Nutrition and Lifestyle Influences on Age-Related Frailty and Sarcopenia

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: 5 May 2026 | Viewed by 1435

Special Issue Editor


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Guest Editor
1. Internal Medicine Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
2. Division of Immunology, Transplantation and Infectious Diseases, Vita-Salute San Raffaele University, 20100 Milan, Italy
Interests: frailty; respiratory dysfunction; sarcopenia; geriatrics
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Special Issue Information

Dear Colleagues,

Aging is associated with an increased risk of frailty and sarcopenia, conditions that significantly impact mobility, independence, and overall quality of life. Emerging evidence suggests that nutrition and lifestyle factors play a crucial role in mitigating these conditions, offering potential strategies for prevention and management.

This Special Issue of Nutrients aims to explore the complex interplay between diet, physical activity, and other lifestyle behaviors in relation to frailty and sarcopenia in aging populations. We welcome original research articles, systematic reviews, and meta-analyses that investigate key topics, including (but not limited to) the following:

  • The role of protein intake, amino acid supplementation, and dietary patterns in muscle mass preservation.
  • The impact of micronutrients, antioxidants, and anti-inflammatory diets on sarcopenia progression.
  • Lifestyle interventions combining nutrition, exercise, and behavioral strategies to prevent frailty.
  • The gut–muscle axis and the influence of the microbiome on muscle health.
  • The effects of intermittent fasting, caloric restriction, and other dietary approaches on muscle function.

This Special Issue provides a platform for advancing scientific understanding and translating research into practical recommendations for healthy aging. We look forward to receiving your contributions to this important area of research.

Dr. Sarah Damanti
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • frailty
  • sarcopenia
  • aging
  • nutrition
  • dietary interventions
  • muscle health
  • protein intake
  • physical activity
  • gut–muscle axis
  • lifestyle factors

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Published Papers (1 paper)

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19 pages, 1199 KB  
Systematic Review
Berries derived Polyphenols and Bone Health: A Systematic Review
by Simone Perna, Giorgia F. Ruina, Asmita Acharya, Giuseppe Mazzola, Mariangela Rondanelli and Patrizia Riso
Nutrients 2025, 17(21), 3440; https://doi.org/10.3390/nu17213440 - 31 Oct 2025
Viewed by 1028
Abstract
Background: Oxidative stress and inflammation contribute to osteoporosis. Berries provide polyphenols especially anthocyanins that may modulate bone remodeling. This review is the first to synthesize evidence specifically on berries and bone health, integrating human, animal, and in vitro data under the GRADE [...] Read more.
Background: Oxidative stress and inflammation contribute to osteoporosis. Berries provide polyphenols especially anthocyanins that may modulate bone remodeling. This review is the first to synthesize evidence specifically on berries and bone health, integrating human, animal, and in vitro data under the GRADE framework. Methods: We systematically searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library through 23 April 2025 for human, animal, and in vitro studies on berries or berry-derived compounds and bone outcomes. Risk of bias was assessed with RoB 2.0, ROBINS-I, SYRCLE, and an adapted ToxRTool; certainty of human evidence was appraised with GRADE. Results: Nineteen studies were included (5 human, 9 in vivo, 5 in vitro). Observational cohorts linked higher anthocyanin intake with greater BMD. Small randomized trials suggested modest benefits of blackcurrant and blueberry on whole-body BMD, bone turnover markers, and calcium retention, while results for biomarkers were mixed. Animal models generally showed attenuation of ovariectomy- or age-related bone loss, and in vitro experiments indicated inhibition of osteoclastogenesis with stimulation of osteoblast activity. By GRADE, certainty was low–moderate for BMD, low for biomarkers, and very low for fractures. Conclusions: Berry polyphenols may support skeletal health via antioxidant and anti-resorptive mechanisms, but current clinical evidence is limited by small samples, heterogeneity, and lack of fracture outcomes. Larger, longer, standardized RCTs with exposure profiling are needed before dietary recommendations can be made. Full article
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