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Prebiotics and the Mind: Exploring Connections to Mental Health and Psychiatric Outcomes

A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Prebiotics, Probiotics and Postbiotics".

Deadline for manuscript submissions: 15 February 2027 | Viewed by 1114

Editors

Department of Basic Medical Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantynów 1H, 20-708 Lublin, Poland
Interests: nutritional psychiatry; gut-brain axis; inflammation; personalized medicine; gut permeability; lifestyle psychiatry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
UC-Research Institute for Sport and Exercise (UCRISE), University of Canberra, Canberra, ACT 2601, Australia
Interests: exercise physiology; physical activity; exercise science; exercise testing; muscle; inflammation; strength & conditioning; exercise intervention; mental health; mental illness
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The relationship between prebiotics and mental health has gained increasing attention, particularly within the framework of the gut–brain (gut–microbiota–brain) axis. Emerging evidence suggests that dietary prebiotics may influence mood, depressive symptoms, and stress-related outcomes, indicating their potential role as a supportive strategy for mental health and as an adjunctive therapy in psychiatric disorders.

Most existing research has focused on mood and anxiety symptoms, often emphasizing probiotics rather than prebiotics. Evidence regarding the effects of prebiotics in psychiatric populations and individuals with neurodevelopmental disorders remains limited. Although dietary prebiotics may exert broad effects on emotional and stress responses, current findings are inconsistent. These discrepancies likely result from heterogeneous study designs, differences in prebiotic type, dosage, duration of intervention, and interindividual variability in gut microbiota composition, making it difficult to draw firm conclusions.

While promising results have been reported in adults, the impact of prebiotics on mental health outcomes in children and adolescents is still underexplored and requires further investigation.

This Special Issue aims to highlight the effects of prebiotics on mental health and psychiatric outcomes in both healthy individuals and patients with psychiatric disorders, with a particular emphasis on their role as adjunctive therapy. Studies exploring underlying mechanisms of action within the gut–brain axis are especially welcome. We invite original research articles, reviews, systematic reviews, and meta-analyses from both human and experimental studies.

Dr. Joanna Rog
Dr. Andrew McKune
Guest Editors

Manuscript Submission Information

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Keywords

  • prebiotics
  • gut-brain axis
  • mental health
  • nutritional psychiatry
  • gut microbiome
  • mood disorders

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Published Papers (1 paper)

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Review

34 pages, 3204 KB  
Review
Sleep as a Transdiagnostic Target in Psychiatry: Prebiotics, the Gut–Brain Axis, and the Gap Between Mechanistic Plausibility and Clinical Evidence
by Giuseppe Marano, Elena Lucia Valle, Giulio Carriero, Caterina Brisi, Gianandrea Traversi, Osvaldo Mazza, Gabriele Sani and Marianna Mazza
Nutrients 2026, 18(14), 2366; https://doi.org/10.3390/nu18142366 - 19 Jul 2026
Viewed by 734
Abstract
Sleep disturbances are highly prevalent across psychiatric disorders and represent both a clinical feature and a potential transdiagnostic therapeutic target. Growing evidence suggests that the gut microbiota may contribute to sleep regulation through immune, metabolic, circadian, and neuroendocrine pathways. Prebiotics, defined as selectively [...] Read more.
Sleep disturbances are highly prevalent across psychiatric disorders and represent both a clinical feature and a potential transdiagnostic therapeutic target. Growing evidence suggests that the gut microbiota may contribute to sleep regulation through immune, metabolic, circadian, and neuroendocrine pathways. Prebiotics, defined as selectively utilized substrates that confer health benefits through modulation of host microorganisms, have received increasing attention as nutritional strategies capable of influencing the gut–brain axis. This narrative review summarizes preclinical and human evidence on prebiotic interventions in relation to sleep-related outcomes and psychiatric symptomatology, with particular attention to short-chain fatty acids, circadian regulation, inflammatory pathways, stress-related hypothalamic–pituitary–adrenal axis activity, and microbial metabolite signaling. Preclinical studies suggest that selected prebiotics may influence sleep architecture, stress resilience, neuroinflammation, and behavioral phenotypes, particularly under conditions of stress or sleep disruption, but translation to human populations remains preliminary. Available clinical studies are limited by small sample sizes, heterogeneous prebiotic formulations, variable doses and intervention durations, inconsistent microbiome methodologies, and frequent reliance on subjective sleep measures rather than polysomnography or actigraphy. Therefore, current evidence supports prebiotics as biologically plausible and generally well-tolerated adjunctive strategies, but not as established treatments for insomnia or psychiatric symptoms. Sleep may provide a clinically meaningful transdiagnostic framework for future nutritional psychiatry research, provided that adequately powered randomized controlled trials integrate objective sleep assessment, standardized microbiome and metabolomic profiling, and clinically relevant psychiatric outcomes. Full article
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