Bioactive Compounds of Nutraceuticals and Functional Foods for Healthy Brain Ageing: From Bench to Diet
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Neuro Sciences".
Deadline for manuscript submissions: 15 September 2026 | Viewed by 745
Special Issue Editors
Interests: brain ageing; brain neoplasms; neurodegenerative diseases; neuroprotection; neuroinflammation; cellular senescence; postbiotics; bioactive compounds in diet
Interests: bioactive peptides; therapeutic peptides; food-derived peptides; neuroprotection; anti-inflammatory activity; anti-aging peptides; neuroplasticity; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Healthy brain aging is increasingly challenged by chronic, oxidative, and inflammatory processes, referred to as “oxy‑inflamm‑aging”.
These mechanisms contribute to neuronal damage, impaired synaptic plasticity, cognitive decline, and increased risk of neurodegenerative diseases. Growing evidence indicates that bioactive compounds present in nutraceuticals and functional foods can beneficially modulate oxidative stress, systemic and neuro‑inflammation, and key molecular pathways essential for maintaining brain plasticity and resilience.
This Special Issue invites original research and comprehensive reviews that advance our understanding of how diet‑derived molecules may counteract oxy‑inflamm‑aging, prevent cytotoxic exo- and endogenous insults, support neuronal health, and promote cognitive longevity.
We are particularly interested in translational studies that highlight compounds targeting molecular and cellular processes contributing to brain ageing, providing a background for developing evidence-based dietary products for improved health outcomes.
We are looking for investigations focusing on substances beneficial for the following:
- The prophylaxis and supportive management of age‑related CNS disorders, including neurodegenerative diseases and brain malignancies;
- Mitigating accelerated brain ageing and cognitive dysfunction resulting from treatment‑related side effects (e.g., oncotherapy);
- Preventing molecular and cellular damage in CNS cells induced by external stressors, such as environmental, dietary, or therapy‑related stressors, that contribute to brain ageing;
- Enhancing neuroplasticity and cognitive function throughout the ageing process.
Dr. Monika Witusik-Perkowska
Dr. Renata Perlikowska
Guest Editors
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Keywords
- brain ageing
- neuroprotection
- oxidative stress and chronic neuroinflammation
- cellular senescence
- autophagy and protein turnover
- age-related DNA alterations and epigenetic modification
- mitochondrial dysfunction
- blood–brain barrier functionality
- neurodegenerative diseases
- gut–brain axis
- nutritional neuroscience
- phytochemicals and bioactive compounds of natural origin
- translational nutrition
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