Optimizing Nutritional Strategies for Cystic Fibrosis: Mechanisms, Interventions, and Clinical Outcomes
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: 25 June 2026
Special Issue Editor
Interests: cystic fibrosis; gastroenterology; nutrition, irritable bowel syndrome; 22q deletion syndrome, pediatric; integrative health, wellness education
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nutrition in cystic fibrosis (CF) is undergoing a paradigm shift as highly effective CFTR modulator therapies (HEMT) redefine clinical management. Historically, emphasis was placed on hypercaloric, high‑fat diets to mitigate malabsorption and elevated energy expenditure, with pancreatic enzyme replacement therapy (PERT), sodium supplementation, and fat‑soluble vitamins constituting the cornerstone of nutritional care. Malnutrition and impaired growth trajectories were primary concerns. With HEMT improving pulmonary function, reducing exacerbations, and extending survival, the nutritional landscape now includes the rising prevalence of overweight and obesity. Consequently, traditional anthropometric targets, such as weight‑for‑length and body mass index (BMI), require reevaluation. Emerging evidence underscores the prognostic significance of lean body mass, necessitating refined methodologies for body composition assessment and a deeper understanding of the metabolic sequelae of excess adiposity.
Advances in microbiome science highlight the potential role of dietary modulation, including anti‑inflammatory diet, in optimizing physical and mental health outcomes. Enhanced screening for disordered eating behaviors is also warranted to delineate their prevalence in CF populations. Moreover, the impact of HEMT on pancreatic function, nutrient absorption, PERT dosing, electrolyte requirements, micronutrient status, and skeletal health must be systematically investigated. Finally, cystic fibrosis-related diabetes (CFRD) persists as a major complication, requiring nuanced strategies to balance nutritional adequacy with glycemic control.
Prof. Dr. Maria R. Mascarenhas
Guest Editor
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Keywords
- cystic fibrosis
- nutrition
- gastroenterology
- eating disorders
- HEMT
- CFRD
- bone health
- PERT
- microbiome
- body composition
- pancreas
- vitamins
- salt
- diet
- mental health
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