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Nutrients
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Metabolomics and Nutrition: From Bench to Bedside
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Metabolomics and Nutrition: From Bench to Bedside

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 5 May 2026 | Viewed by 238

Special Issue Editor

Dr. Ghada Soliman

E-Mail Website
Guest Editor
Department of Environmental, Occupational and Geospatial Health Sciences, The City University of New York, Graduate School of Public Health and Health Policy, 55 West 125th St, New York, NY 10027, USA
Interests: metabolic pathways; untargeted metabolomics; high-resolution metabolomics; targeted metabolomics; precision nutrition; exposome; mechanistic target of rapamycin complexes pathways; cardiovascular kidney metabolic (CKM) health; public health outcomes; food is medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

I am delighted to invite you to contribute an article to this new Special Issue of Nutrients, entitled “Metabolomics and Nutrition: From Bench to Bedside”, for which I serve as Guest Editor. This Special Issue is focused on the role of metabolomics, both targeted and untargeted high-resolution metabolomics, and health outcomes.

Metabolomics is the study of metabolites, the small molecules within cells, tissues, biofluids, organs, body systems, or whole organisms that function as a readout of the totality of exposures. They provide a detailed snapshot of biochemical activity and metabolic status in response to nutrients, environmental influences, and lifestyle factors. As a promising field at the intersection of systems biology and precision medicine, metabolomics offers insights into the complex biochemical processes that underpin health outcomes and disease states. Applications of metabolomics as a proxy of the internal exposome may include the following: understanding disease causality and mechanisms; biomarkers and diagnostic tools using blood samples or biological fluids; identifying exposure-related metabolite changes; therapeutic insights; and precision nutrition. This approach is pivotal to understanding the relationship between metabolic alterations and health outcomes, especially in the context of chronic diseases like cancer, diabetes, and metabolic disorders. All manuscripts addressing metabolomics and nutrition from mechanistic cell culture, animal model, and human studies are welcome to be submitted.

Dr. Ghada Soliman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • untargeted metabolomics
  • high-resolution metabolomics
  • targeted metabolomics
  • precision nutrition
  • exposomics
  • exposure health outcome causality

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Published Papers (2 papers)

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Research

13 pages, 5494 KB  
Article
Unraveling Stage-Specific Metabolites in Human Milk and Their Links to Maternal Physiology: Insights from a Mexican Population
by Imelda Cecilia Zarzoza-Mendoza, Maricela Rodríguez-Cruz, María Cristina Carmona-Isunza, Hilda Sánchez-Vidal, José Carlos Páez-Franco, Cristian Emmanuel Luna-Guzmán, Maricela Morales-Marzana, Juan Manuel Domínguez-Salgado, Judith Villa-Morales and Lourdes Barbosa-Cortés
Nutrients 2025, 17(21), 3439; https://doi.org/10.3390/nu17213439 (registering DOI) - 31 Oct 2025
Abstract
Background/Objective: Human milk is an irreplaceable source of nutrition and is essential for the infant’s growth and development right after birth and for early life stage survival. This study aims to characterize and compare the metabolite profiles of colostrum and transitional and mature [...] Read more.
Background/Objective: Human milk is an irreplaceable source of nutrition and is essential for the infant’s growth and development right after birth and for early life stage survival. This study aims to characterize and compare the metabolite profiles of colostrum and transitional and mature milk using an untargeted GC-MS approach. Additionally, it explores potential correlations between the identified metabolites and maternal nutritional factors. Methods: This was a longitudinal, prospective, and observational study. We included human milk samples from 113 Mexican women who practiced exclusive breastfeeding. Partial least squares-discriminant analysis (PLS-DA) was performed to assess differences among lactation stages. Metabolites showing significant variation across lactation stages were further analyzed using Friedman tests with post hoc Wilcoxon tests and Bonferroni correction. Correlations with maternal anthropometric measures were evaluated. Results: Twenty-three metabolites were identified, including amino acids and derivatives, sugars, fatty acids, and energetic metabolites. Alanine and creatinine levels decreased during lactation, while aspartate, serine, and valine levels increased. Rhamnose level was higher in colostrum, whereas decanoic, dodecanoic, and tetradecanoic acid levels increased over time, and that of 11,14-eicosadienoic acid decreased. Lactic acid levels declined across stages. Negative correlations were found between several amino acids and maternal anthropometric variables, while glyceric acid, rhamnose and lactic acid correlated positively. Conclusions: Human milk metabolomic profiles display distinct, stage-specific variations shaped by maternal characteristics, reflecting the dynamic physiological and nutritional demands of the developing infant Full article
(This article belongs to the Special Issue Metabolomics and Nutrition: From Bench to Bedside)
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23 pages, 6518 KB  
Article
Hyocholic Acid Species as the Key Modulator for Cecal Epithelial Homeostasis in Low-Birth-Weight Piglets
by Chang Yin, Xuan Liu, Wei Fang, Qingshi Meng, Xiaohui Feng, Weidong Zhang, Guoqi Dang, Ruqing Zhong, Liang Chen, Zirong Wang and Hongfu Zhang
Nutrients 2025, 17(21), 3415; https://doi.org/10.3390/nu17213415 - 30 Oct 2025
Abstract
Background: Low birth weight (LBW) is correlated with gut microbiota dysbiosis and intestinal barrier function disruption, increasing susceptibility to enteric diseases. These alterations underscore the critical need to identify key regulators of gut homeostasis, among which bile acids are increasingly recognized as [...] Read more.
Background: Low birth weight (LBW) is correlated with gut microbiota dysbiosis and intestinal barrier function disruption, increasing susceptibility to enteric diseases. These alterations underscore the critical need to identify key regulators of gut homeostasis, among which bile acids are increasingly recognized as pivotal for barrier integrity, microbial ecology, and host metabolism. Methods: Eight pairs of LBW (the initial BW was 0.850 ± 0.053 kg) and normal-birth-weight (NBW; 1.488 ± 0.083 kg) piglets were compared to evaluate cecal morphology and bile acid profiles. Subsequently, sixteen LBW piglets and eight NBW piglets were allocated into three groups: NBW (1.563 ± 0.052 kg), LBW control (LBW-CON; 0.950 ± 0.120 kg), and LBW with bile acid supplementation (LBW-bile powder; 0.925 ± 0.116 kg). Piglets in the LBW-bile powder group received 25 mg/kg BW of bile powder (hyodeoxycholic acid-enriched) by daily oral gavage for 14 days. Results: LBW piglets exhibited retarded cecal development and lower abundance of hyocholic acid species (p = 0.006). Importantly, bile powder supplementation significantly improved cecal length (p = 0.009) and mucosal thickness (p = 0.020) compared with LBW-CON piglets. Microbial analysis showed that the microbial dysbiosis index was restored to near-normal levels. Transcriptomic analysis revealed impaired extracellular matrix structure and mucus secretion in LBW piglets. Notably, bile powder supplementation markedly upregulated the protein expression of WNT8B (p < 0.001) and the bile acid receptors (i.e., GPBAR1 and FXR), alongside enhanced tight junctions and the goblet cell marker mucin-2 expression (p < 0.05). Conclusions: These findings suggest that specific bile acid supplementation improves gut barrier function and partially supports cecal development in LBW piglets. Full article
(This article belongs to the Special Issue Metabolomics and Nutrition: From Bench to Bedside)
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