nutrients-logo

Journal Browser

Journal Browser

Nutrition and Gut Microbiome in the Prevention of Food Allergy

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 2135

Special Issue Editors


E-Mail Website
Guest Editor
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), National Council of Research, ISPA-CNR, Via Amendola 122/O, 70126 Bari, Italy
Interests: diet and nutrition; gut micriobiome; metabolite profiling; food allergy; proteomics; allergen discovery; allergenicity assessment
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Translational Research in Pediatric Specialities, Division of Allergy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy
Interests: food allergy; anaphylaxis; children; pediatric allergy

Special Issue Information

Dear Colleagues,

In recent years, the gut microbiome has represented an emerging area of investigation with a growing trend of publications in the field of nutrition and gut microbiota, reportedly to be increased by tenfold in the last decade.

In particular, targeted nutrition has gained significant attention to assist consumers in making healthy food choices and reducing the risk factor of noncommunicable diseases (NCDs), also including food allergies, as this was found to be associated with changes in the commensal microbiome.

Prebiotics and probiotics have been shown to have a role in modulating the inflammatory immonoresponse, thus altering the adverse reactions displayed in allergic consumers.

Probiotics show promise in preventing and managing food allergies, but the impact of supplementation during pregnancy or infancy on children's allergies and gut microbiota remains unclear.

Postbiotics have also recently emerged as a promising alternative to the use of probiotics, although more research is required in this field to elucidate their role in food allergy prevention.

This Special Issue aims to explore the intriguing connection between nutrition, the gut microbiome, and food allergy through a healthy and/or supplemented diet.

Identifying a targeted nutrition for allergic consumers may lead to alleviating the burden of developing severe reactions for sensitive consumers thanks to the regulation of intestinal flora and metabolite production, becoming more effective in mitigating allergic diseases.

Open questions include the following: Are there predictable factors influencing the interconnection between the gut microbiome and immunological reactions?

Can a targeted nutrition modulate or alter the likelihood of triggering an allergic reaction in sensitive individuals?

How can diet mitigate this?

I invite all the scientific community to contribute to this Special Issue with original research papers and reviews on cutting-edge research focusing on the gut microbiome and food allergies.

Dr. Linda Monaci
Dr. Stefania Arasi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiome
  • nutrition
  • prebiotic and probiotics
  • diet
  • immunomodlatory metabolites
  • IgE-mediated food allergy

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

29 pages, 915 KB  
Review
Gut Microbiota and Food Allergy: A Review of Mechanisms and Microbiota-Targeted Interventions
by Roxana Cristina Mareș, Maria Oana Săsăran and Cristina Oana Mărginean
Nutrients 2025, 17(18), 3009; https://doi.org/10.3390/nu17183009 - 20 Sep 2025
Viewed by 1762
Abstract
Background: Food allergies (FAs) have become a major public health concern worldwide, with rising prevalence particularly among children. Traditional genetic and allergen exposure models do not fully explain this increase, prompting growing interest in the role of the gut microbiota. Early-life microbial [...] Read more.
Background: Food allergies (FAs) have become a major public health concern worldwide, with rising prevalence particularly among children. Traditional genetic and allergen exposure models do not fully explain this increase, prompting growing interest in the role of the gut microbiota. Early-life microbial colonization is now recognized as a critical determinant of immune development, with disruptions in microbial balance implicated in allergic sensitization. Objective: This review aims to synthesize recent human studies investigating the relationship between gut microbiota composition and food allergies, with an emphasis on underlying mechanisms and the potential of microbiota-targeted interventions. Methods: A literature search was conducted, including eligible studies concerning gut microbiota and food allergy. A total of 31 studies met the inclusion criteria. Results: The findings indicate that early-life factors, including delivery mode, feeding practices, antibiotic exposure, and environmental microbial diversity, have a significant influence on gut microbial colonization. Allergic children consistently exhibit reduced microbial diversity and lower levels of beneficial taxa such as Bifidobacteria, Faecalibacteria, and Clostridia. Microbial dysbiosis is associated with enhanced type 2 immune responses, reduced regulatory T cell activity, and altered profiles of short-chain fatty acids. Dietary modulation through prebiotics, probiotics, and synbiotics has shown potential in restoring microbial balance and promoting immune tolerance, although with varying degrees of efficacy depending on the strains, formulas, and timing of intervention. Conclusions: The gut microbiota plays a central role in the pathogenesis and potential prevention of food allergies. Microbiota-targeted dietary strategies, particularly in early life, offer promising avenues for promoting immune tolerance. Full article
(This article belongs to the Special Issue Nutrition and Gut Microbiome in the Prevention of Food Allergy)
Show Figures

Figure 1

Back to TopTop