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Nutrients
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Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and...
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Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and Therapeutic Potential

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 1613

Special Issue Editor

Dr. Weimin Guo

E-Mail Website
Guest Editor
Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, 670 Albany Street, Boston, MA 02118, USA
Interests: nutrition; aging; immunology; obesity; cognitive impairment; atherosclerosis; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic diseases—including cardiovascular disease, type 2 diabetes, cancer, and neurodegenerative disorders—remain leading causes of morbidity and mortality worldwide. Nutritional interventions and dietary supplements are increasingly recognized for their role in preventing disease onset, modulating disease progression, and enhancing therapeutic outcomes.

This Special Issue, “Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and Therapeutic Potential”, aims to highlight the impact of nutrients, bioactive compounds, and functional foods on the prevention and management of chronic conditions. Particular emphasis is placed on elucidating the underlying molecular and cellular mechanisms—including metabolic regulation, immune modulation, oxidative stress response, and epigenetic modification—that mediate their effects.

Despite growing interest and widespread application, critical questions remain regarding the efficacy, safety, and context-dependent actions of nutritional strategies across diverse populations and disease states. We invite high-quality contributions that advance molecular and mechanistic understanding while also addressing clinical and public health relevance.

We welcome original research articles, systematic reviews, meta-analyses, and comprehensive reviews from the fields of molecular nutrition, clinical nutrition, and public health. Submissions may include experimental, clinical, or epidemiological studies involving both healthy individuals and those affected by chronic diseases.

Dr. Weimin Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional intervention
  • dietary supplements
  • bioactive compounds and functional foods
  • micronutrients and phytochemicals
  • molecular mechanisms of action
  • nutritional signaling pathways
  • gut microbiota and probiotics
  • nutritional genomics and epigenetics
  • experimental nutrition models
  • clinical nutrition and chronic disease
  • systematic reviews and meta-analyses

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Published Papers (1 paper)

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26 pages, 677 KB  
Systematic Review
Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as Obesity, Metabolic Syndrome, and Type 2 Diabetes
by Joanna Michalina Jurek, Katarzyna Zablocka-Slowinska, Joanna Pieczynska, Helena Clavero Mestres and Teresa Auguet
Nutrients 2025, 17(18), 3020; https://doi.org/10.3390/nu17183020 - 22 Sep 2025
Viewed by 1254
Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent liver diseases, affecting up to 40% of adults and strongly associated with obesity and metabolic dysfunction. Despite the lack of approved pharmacological treatments, dietary interventions with plant-based foods, [...] Read more.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the most prevalent liver diseases, affecting up to 40% of adults and strongly associated with obesity and metabolic dysfunction. Despite the lack of approved pharmacological treatments, dietary interventions with plant-based foods, including the Mediterranean diet (MED), rich in numerous bioactive compounds may offer benefits for metabolic health and hepatic function. However, the role of individual plant foods in MASLD management remains unclear. Objectives: This review investigates the effects of specific plant-based foods, consumed as part of the MED and Dietary Approaches to Stop Hypertension (DASHs) diet, on metabolic outcomes, including hepatic function, in MASLD patients alone or in combination with comorbidities such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Methods: A systematic search was registered and conducted across nine databases to identify randomized controlled trials (RCTs) carried out in adults with MASLD and published between January 2020 and May 2025, following PRISMA guidelines. Results: Plant-based interventions including oranges, whole-grain products (WGPs), high-fiber buns (HFBs), beetroot juice (BJ), garlic, ginger, flaxseed, spirulina, rapeseed oil, sour tea, and green coffee extract (GCE) demonstrated mixed effects on metabolic and hepatic outcomes. GCE, flaxseed, and rapeseed oil improved anthropometric measures, while sour tea and ginger supported blood pressure control. WGPs, GCE, flaxseed, rapeseed oil, spirulina, ginger, and garlic were beneficial for glycemic regulation, whereas WGPs, HFBs, BJ, golden flaxseed, rapeseed oil, and garlic improved lipid profiles. Liver enzymes improved following consumption of WGPs, BJ, sour tea, flaxseed oil, and garlic, and hepatic steatosis was reduced after intake of oranges, WGPs, HFBs, BJ, flaxseed powder, rapeseed oil, and garlic powder. Conversely, a solely fruit-rich diet (FRD) had negative effects across all outcomes. Conclusions: Plant-based foods improved metabolic outcomes, with WGPs, HFBs, beetroot, oranges, sour tea, flaxseed oil, and garlic providing specific benefits for liver health. Further research is needed to validate these effects and ensure their safety in MASLD management. Full article
(This article belongs to the Special Issue Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and Therapeutic Potential)
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