Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and Therapeutic Potential

Dear Colleagues,

Chronic diseases—including cardiovascular disease, type 2 diabetes, cancer, and neurodegenerative disorders—remain leading causes of morbidity and mortality worldwide. Nutritional interventions and dietary supplements are increasingly recognized for their role in preventing disease onset, modulating disease progression, and enhancing therapeutic outcomes.

This Special Issue, “Nutritional Interventions and Dietary Supplements in Chronic Diseases: Mechanisms and Therapeutic Potential”, aims to highlight the impact of nutrients, bioactive compounds, and functional foods on the prevention and management of chronic conditions. Particular emphasis is placed on elucidating the underlying molecular and cellular mechanisms—including metabolic regulation, immune modulation, oxidative stress response, and epigenetic modification—that mediate their effects.

Despite growing interest and widespread application, critical questions remain regarding the efficacy, safety, and context-dependent actions of nutritional strategies across diverse populations and disease states. We invite high-quality contributions that advance molecular and mechanistic understanding while also addressing clinical and public health relevance.

We welcome original research articles, systematic reviews, meta-analyses, and comprehensive reviews from the fields of molecular nutrition, clinical nutrition, and public health. Submissions may include experimental, clinical, or epidemiological studies involving both healthy individuals and those affected by chronic diseases.

Dr. Weimin Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.