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Advances in Healthy Longevity: Targeting Functional Food Components, Aging Biomarkers and Chronic Disease Risk

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 January 2025) | Viewed by 1907

Special Issue Editors


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Guest Editor
1. Department of Biochemistry, Campus Duques de Soria, University of Valladolid, 42004 Soria, Spain
2. Grupo de Investigación Reconocido “Pharmacogenetics, Cancer Genetics, Genetic, Polymorphisms and Pharmacoepidemiology”, University of Valladolid, 47005 Valladolid, Spain
Interests: chronic disease; genetic polymorphisms; pain; multidisciplinary
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Guest Editor
Translational Research in Aging and Longevity (TRIAL) Group, Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
Interests: diet; biological aging; sarcopenia; skeletal muscle; inflammation; senescence; mitochondrial function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the concept of “healthy longevity” has received widespread attention because it focuses both on increasing an individual’s overall life expectancy or longevity and on extending life without serious chronic diseases or on “healthspan”. The U.S. National Academy of Medicine defines healthspan as “good health, close to biological lifespan, with physical, cognitive, and social functioning, and the ability to achieve well-being”.

Various components of the diet play an important role in regulating the aging process and longevity, as well as the development of age-related diseases. Dietary interventions and functional foods help to promote healthy aging and longevity.

On the other hand, biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. 

The effects of chronic diseases and multimorbidities include disability, reduced quality of life, shorter life expectancy, and greater need for healthcare resources. Identifying multimorbidity and high-risk factors that adversely affect the quality of life of older individuals is a critical public health concern.

This Special Issue aims to advance the role of biomarkers in geriatric nutrition. Potential areas include the following:

- The effects of food components on metabolism and biological markers of aging adults.
- Associations between nutritional biomarkers and biological aging.
- Exploring potential mechanisms by which functional nutrients may prevent age-related diseases, using biomarkers as a lens.
- Geriatric nutritional intervention studies utilizing biomarkers to assess effectiveness.
- Identification of novel aging biomarkers from omics technologies and their association with nutrition.

Prof. Dr. Zoraida Verde Rello
Dr. Marta Gonzalez-Freire
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • healthspan
  • healthy aging
  • biological process
  • biomarkers
  • dietary habits
  • functional foods
  • quality of life
  • chronic diseases
  • multimorbidities

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Published Papers (1 paper)

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Research

17 pages, 965 KiB  
Article
Daily Adequate Intake of Fruit and Vegetables and All-Cause, Cardiovascular Disease, and Cancer Mortalities in Malaysian Population: A Retrospective Cohort Study
by Lay Kim Tan, Nabilah Hanis Zainuddin, Najjah Tohar, Ridwan Sanaudi, Yong Kang Cheah, Mohd Azahadi Omar and Chee Cheong Kee
Nutrients 2024, 16(18), 3200; https://doi.org/10.3390/nu16183200 - 21 Sep 2024
Viewed by 1558
Abstract
Background/Objective: We investigated the relationship between daily adequate FV intake and risk of all-cause, cardiovascular disease (CVD), and cancer mortalities among Malaysian adults. Methods: Data from a total of 18,211 Malaysian adults aged 18 years and above whom participated in the National Health [...] Read more.
Background/Objective: We investigated the relationship between daily adequate FV intake and risk of all-cause, cardiovascular disease (CVD), and cancer mortalities among Malaysian adults. Methods: Data from a total of 18,211 Malaysian adults aged 18 years and above whom participated in the National Health and Morbidity Survey 2011 were analyzed. The participants were followed up for approximately 11 years, and mortality data were ascertained through record linkages with the death registry from the Malaysian National Registration Department. Multiple Cox regression was applied to assess the association between daily adequate FV intake and risk of all-cause, CVD, and cancer mortalities, adjusting for sociodemographic, lifestyle, and health conditions. Results: During the follow-up period, we observed a total of 1809 all-cause, 374 CVD, and 216 cancer mortalities. No significant association between daily adequate FV intake with all-cause mortality (adjusted hazard ratio (aHR): 1.01, 95% confidence interval (CI: 0.79–1.31), CVD mortality (aHR: 0.91, 95% CI: 0.57–1.47), and cancer mortality (aHR: 1.27, 95% CI: 0.74–2.17) were observed, even after excluding deaths that occurred in the first two years of observation. Conclusions: Further investigation on the type of FV intake and its preparation method with risk of mortality will provide a holistic insight into the causal relationship between FV intake and mortality. Full article
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