Innovations in Acute Stroke Treatment, Neuroprotection, and Recovery

A special issue of Neurology International (ISSN 2035-8377).

Deadline for manuscript submissions: 30 October 2025 | Viewed by 220

Special Issue Editor

Special Issue Information

Dear Colleagues,

The treatment of acute ischemic stroke has altered significantly with the advent of reperfusion therapies, yet critical challenges related to the optimization of neuroprotection, the mitigation of secondary injury, and the enhancement of post-stroke recovery remain. This Special Issue, entitled "Innovations in Acute Stroke Treatment, Neuroprotection, and Recovery", aims to present cutting-edge advancements that address these challenges and redefine stroke care, from hyperacute intervention to long-term functional restoration.

This Special Issue will explore the latest breakthroughs in thrombolysis, endovascular thrombectomy, and adjunctive neuroprotective strategies, providing mechanistic insights into ischemia–reperfusion injury, blood–brain barrier dysfunction, and inflammatory cascades. We particularly encourage contributions that address emerging molecular targets for neuroprotection, novel imaging biomarkers for precision therapy, and the integration of artificial intelligence into treatment decision-making.

Additionally, we seek high-impact studies on post-stroke recovery, including neuroplasticity-driven rehabilitation, brain–computer interfaces, neuromodulation, and personalized strategies that prevent stroke-related cognitive impairment. This Special Issue will particularly focus on translational research that integrates preclinical discoveries with real-world clinical applications, as well as approaches to health systems that reduce disparities and improve outcomes across diverse populations.

By compiling multidisciplinary articles concerning stroke pathophysiology, intervention, and recovery, this Special Issue aims to push the boundaries of stroke research and accelerate the transition toward precision medicine in cerebrovascular care.

Dr. Sonu M. M. Bhaskar
Guest Editor

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Keywords

  • stroke
  • reperfusion therapy
  • imaging
  • biomarkers
  • disease burden
  • pathophysiology
  • stroke care
  • neuroprotective
  • post-stroke recovery

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Published Papers (1 paper)

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Research

14 pages, 664 KiB  
Article
The Association of Cerebral Blood Flow Measured Using Extracranial Carotid Ultrasound with Functional Outcomes in Patients with Anterior Circulation Large Vessel Occlusion After Endovascular Thrombectomy—A Retrospective Study
by Xin-Hong Lin, Kuan-Wen Chen, Chung-Fu Hsu, Ting-Wei Chang, Chao-Yu Shen and Hsin-Yi Chi
Neurol. Int. 2025, 17(5), 67; https://doi.org/10.3390/neurolint17050067 - 25 Apr 2025
Viewed by 98
Abstract
Background: Endovascular mechanical thrombectomy (EVT) is regarded as the standard treatment for acute ischemic stroke with large vessel occlusion. Few studies have examined the evolution of cerebral flow after the acute stage of ischemic stroke. In this study, we examined the association [...] Read more.
Background: Endovascular mechanical thrombectomy (EVT) is regarded as the standard treatment for acute ischemic stroke with large vessel occlusion. Few studies have examined the evolution of cerebral flow after the acute stage of ischemic stroke. In this study, we examined the association of functional outcomes with cerebral blood flow by extracranial carotid sonography during the subacute phase after EVT and multiple prognostic variables. Methods: We conducted a single-center, retrospective, observational study between January 2018 and June 2023. Patients with acute stroke resulting from anterior circulation large vessel occlusion who underwent EVT were included. All patients underwent carotid sonography in the second week after EVT. Patients with fair (modified Rankin Scale [mRS]: 0–3) and poor outcomes (mRS: 4–6) were compared to determine the association between and identify the predictors of these factors and functional outcomes. Results: A total of 89 patients were included (female: 38 (42.7%); mean age: 69.45 ± 13.59 years). Multivariable logistic regression analysis revealed that three factors were independent predictors of fair outcomes: (1) the Alberta Stroke Program Early CT Score (odds ratio [OR]: 1.79; 95% confidence interval [CI]: 1.16–2.78; p = 0.009); (2) Thrombolysis in Cerebral Infarction 2b to 3 (OR: 4.91; 95%CI: 1.10–21.89; p = 0.037); (3) the ratio of treatment-side blood flow between the internal carotid artery and common carotid artery (QTI/QTC, OR: 45.35; 95% CI: 1.11–1847.51; p = 0.04). Conclusions: The ratio of QTI/QTC is a clinically relevant parameter as a potential predictor of favorable outcomes. This parameter can be used to formulate patient prognostic scores and help clinicians determine whether adequate cerebral perfusion is maintained during the subacute phase. Full article
(This article belongs to the Special Issue Innovations in Acute Stroke Treatment, Neuroprotection, and Recovery)
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