Next Article in Journal / Special Issue
Strengths and Weaknesses of the Current Strategies to Map and Characterize R-Loops
Previous Article in Journal
The Role of Long Non-Coding RNAs in Osteosarcoma
Open AccessFeature PaperReview

RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance

Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(1), 8;
Received: 8 February 2018 / Revised: 5 March 2018 / Accepted: 8 March 2018 / Published: 11 March 2018
(This article belongs to the Special Issue Genomic Instability and Non-Coding RNA)
The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substrates and the structural basis of its functions. In addition to the exosome itself, recent studies focusing on associated co-factors have been elucidating how the exosome is directed towards specific substrates. Moreover, it has been gradually realized that loss-of-function of exosome subunits affect multiple biological processes, such as the DNA damage response, R-loop resolution, maintenance of genome integrity, RNA export, translation, and cell differentiation. In this review, we summarize the current knowledge of the mechanisms of nuclear exosome-mediated RNA metabolism and discuss their physiological significance. View Full-Text
Keywords: exosome; RNA surveillance; RNA processing; RNA degradation exosome; RNA surveillance; RNA processing; RNA degradation
Show Figures

Graphical abstract

MDPI and ACS Style

Ogami, K.; Chen, Y.; Manley, J.L. RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance. Non-Coding RNA 2018, 4, 8.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop