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Non-Coding RNA 2018, 4(1), 8;

RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance

Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Author to whom correspondence should be addressed.
Received: 8 February 2018 / Revised: 5 March 2018 / Accepted: 8 March 2018 / Published: 11 March 2018
(This article belongs to the Special Issue Genomic Instability and Non-Coding RNA)
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The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substrates and the structural basis of its functions. In addition to the exosome itself, recent studies focusing on associated co-factors have been elucidating how the exosome is directed towards specific substrates. Moreover, it has been gradually realized that loss-of-function of exosome subunits affect multiple biological processes, such as the DNA damage response, R-loop resolution, maintenance of genome integrity, RNA export, translation, and cell differentiation. In this review, we summarize the current knowledge of the mechanisms of nuclear exosome-mediated RNA metabolism and discuss their physiological significance. View Full-Text
Keywords: exosome; RNA surveillance; RNA processing; RNA degradation exosome; RNA surveillance; RNA processing; RNA degradation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ogami, K.; Chen, Y.; Manley, J.L. RNA Surveillance by the Nuclear RNA Exosome: Mechanisms and Significance. Non-Coding RNA 2018, 4, 8.

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