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Long Non-Coding RNAs in Obesity-Induced Cancer

School of Medical and Health Sciences, Tung Wah College, Hong Kong, China
Department of Medicine, The University of Hong Kong, Hong Kong, China
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(3), 19;
Received: 24 June 2018 / Revised: 22 August 2018 / Accepted: 27 August 2018 / Published: 28 August 2018
(This article belongs to the Special Issue Genomic Instability and Non-Coding RNA)
Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity. View Full-Text
Keywords: obesity; cancer; lncRNA; ANRIL; H19; HOTAIR obesity; cancer; lncRNA; ANRIL; H19; HOTAIR
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MDPI and ACS Style

Yau, M.Y.-C.; Xu, L.; Huang, C.-L.; Wong, C.-M. Long Non-Coding RNAs in Obesity-Induced Cancer. Non-Coding RNA 2018, 4, 19.

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