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Non-Coding RNA 2018, 4(3), 19; https://doi.org/10.3390/ncrna4030019

Long Non-Coding RNAs in Obesity-Induced Cancer

1
School of Medical and Health Sciences, Tung Wah College, Hong Kong, China
2
Department of Medicine, The University of Hong Kong, Hong Kong, China
3
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China
*
Author to whom correspondence should be addressed.
Received: 24 June 2018 / Revised: 22 August 2018 / Accepted: 27 August 2018 / Published: 28 August 2018
(This article belongs to the Special Issue Genomic instability and Non-Coding RNA)
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Abstract

Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity. View Full-Text
Keywords: obesity; cancer; lncRNA; ANRIL; H19; HOTAIR obesity; cancer; lncRNA; ANRIL; H19; HOTAIR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yau, M. .-C.; Xu, L.; Huang, C.-L.; Wong, C.-M. Long Non-Coding RNAs in Obesity-Induced Cancer. Non-Coding RNA 2018, 4, 19.

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