Nanotechnology for Biofilm Prevention, Treatment and Diagnosis

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (16 December 2019) | Viewed by 9299

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, Groningen, University of Groningen, University Medical Center Groningen, The Netherlands
Interests: biofilms; bioadhesion; biomaterials; biofilm prevention; drug release

Special Issue Information

Dear Colleagues,

Microbial biofilm formation constitutes the main reason for biomaterial associated infections around catheters, orthopaedic, trauma, dental implants, and many other biomedical devices, and complicates and impairs the healing of chronic wounds, such as in diabetic foot ulcers and non-healing skin wounds. The biofilm matrix acts as a protective barrier and prevents nutrients from penetrating into the deeper layers of a biofilm causing low susceptibility of organisms to antimicrobials and the host immune system. Main strategies to fight biofilms are either based on preventing biofilm formation, on penetration and the killing of bacteria or fungi in biofilms or finally biofilm debridement. Many of these strategies may involve nanotechnology, e.g., nano patterned surface coatings, release of antimicrobial nanoparticles, graphene-based nanomaterials, responsive nanocomposite coatings, and drug delivery from nanoparticles. The treatment and prevention of biofilms are extremely complex and have sparked a great deal of interest. Biofilm diagnosis, detection and staging, particularly in clinical settings, however, are still far from mature and may benefit from nanotechnology as well, such as in smart dressing designs and tracer development. This Special Issue of Nanomaterials (Current Impact Factor: 3.504, JCR category rank: 71/285 (Q1) in ‘Materials Science, Multidisciplinary’; 39/92 (Q2) in ‘Nanoscience & Nanotechnology’), “Nanotechnology for Biofilm Prevention, Treatment and Diagnosis”, aims at collecting a compilation of articles that strongly demonstrate the continuous efforts in developing advanced and safe nanomaterial-based technologies to diagnose and fight microbial biofilms.

Dr. Jelmer Sjollema
Guest Editor

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Keywords

  • Biofilm
  • Nano topography
  • Drug delivery
  • Biofilm diagnosis
  • Responsive coatings
  • Multifunctional coatings
  • Microgels
  • Micelles
  • Liposomes
  • Bilayers

Published Papers (2 papers)

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Research

12 pages, 3607 KiB  
Article
Inhibitory Activity of Silver Nanoparticles Synthesized Using Lycopersicon Esculentum against Biofilm Formation in Candida Species
by Jeong Su Choi, Ji Woong Lee, Un Chul Shin, Min Woo Lee, Dae Jin Kim and Suhng Wook Kim
Nanomaterials 2019, 9(11), 1512; https://doi.org/10.3390/nano9111512 - 23 Oct 2019
Cited by 22 | Viewed by 3939
Abstract
This paper investigated the antifungal and antibiofilm activity of silver nanoparticles synthesized with Lycopersicon esculentum extracts against Candida species. Lycopersicon esculentum extracts obtained by homogenization were mixed with silver nitrate to synthesize silver nanoparticles. Analysis of the particle characteristics by UV–Vis spectrophotometry, scanning [...] Read more.
This paper investigated the antifungal and antibiofilm activity of silver nanoparticles synthesized with Lycopersicon esculentum extracts against Candida species. Lycopersicon esculentum extracts obtained by homogenization were mixed with silver nitrate to synthesize silver nanoparticles. Analysis of the particle characteristics by UV–Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR) confirmed that the Lycopersicon esculentum extracts effectively served as reductants and capping agents. Minimum inhibitory concentration (MIC) tests were conducted to confirm antifungal activity against Candida species. In all the tested species, the silver nanoparticles inhibited the growth of Candida. Moreover, the SEM images of Candida species treated with silver nanoparticles synthesized using natural extracts of Lycopersicon esculentum showed that silver nanoparticles adhered to the surface of Candida, which induced pore formation in the membranes and prevented their normal growth. Ultimately, these abnormal forms of Candida were thought to be less able to form biofilms than normal Candida. The antifungal and antibiofilm activities of silver nanoparticles against Candida are expected to be utilized in various fields and contribute in particular to developments in nanomedicine. Full article
(This article belongs to the Special Issue Nanotechnology for Biofilm Prevention, Treatment and Diagnosis)
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14 pages, 1828 KiB  
Article
High Stability Thiol-Coated Gold Nanostars Monolayers with Photo-Thermal Antibacterial Activity and Wettability Control
by Davide Rovati, Benedetta Albini, Pietro Galinetto, Pietro Grisoli, Barbara Bassi, Piersandro Pallavicini, Giacomo Dacarro and Angelo Taglietti
Nanomaterials 2019, 9(9), 1288; https://doi.org/10.3390/nano9091288 - 9 Sep 2019
Cited by 32 | Viewed by 4115
Abstract
The adhesion and proliferation of bacteria on abiotic surfaces pose challenges in both health care and industrial applications. Gold nanostars (GNSs) monolayers grafted on glass have demonstrated to exert antibacterial action due to their photo-thermal features. Here, these GNS layers were further functionalized [...] Read more.
The adhesion and proliferation of bacteria on abiotic surfaces pose challenges in both health care and industrial applications. Gold nanostars (GNSs) monolayers grafted on glass have demonstrated to exert antibacterial action due to their photo-thermal features. Here, these GNS layers were further functionalized using thiols monolayers, in order to impart different wettability to the surfaces and thus adding a feature that could help to fight bacterial proliferation. Thiol that has different functional groups was used and the thiol-protected surfaces were characterized by means of UV-vis spectroscopy, contact angles, SEM and surface enhanced Raman spectroscopy (SERS). We verified that (i) coating with the proper thiol allows us to impart high hydrophilicity or hydrophobicity to the surfaces (with contact angle values ranging from 10 to 120°); (ii) GNS monolayers are strongly stabilized by functionalization with thiols, with shelf stability increasing from a few weeks to more than three months and (iii) photo-thermal features and subsequent antibacterial effects caused by hyperthermia are not changed by thiols layers, allowing us to kill at least 99.99% of representative bacterial strains. Full article
(This article belongs to the Special Issue Nanotechnology for Biofilm Prevention, Treatment and Diagnosis)
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