Special Issue "Nanotechnology for Biofilm Prevention, Treatment and Diagnosis"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 16 December 2019.

Special Issue Editor

Guest Editor
Dr. Jelmer Sjollema Website E-Mail
University of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Groningen, Netherlands
Interests: biofilms; bioadhesion; biomaterials; biofilm prevention; drug release

Special Issue Information

Dear Colleagues,

Microbial biofilm formation constitutes the main reason for biomaterial associated infections around catheters, orthopaedic, trauma, dental implants, and many other biomedical devices, and complicates and impairs the healing of chronic wounds, such as in diabetic foot ulcers and non-healing skin wounds. The biofilm matrix acts as a protective barrier and prevents nutrients from penetrating into the deeper layers of a biofilm causing low susceptibility of organisms to antimicrobials and the host immune system. Main strategies to fight biofilms are either based on preventing biofilm formation, on penetration and the killing of bacteria or fungi in biofilms or finally biofilm debridement. Many of these strategies may involve nanotechnology, e.g., nano patterned surface coatings, release of antimicrobial nanoparticles, graphene-based nanomaterials, responsive nanocomposite coatings, and drug delivery from nanoparticles. The treatment and prevention of biofilms are extremely complex and have sparked a great deal of interest. Biofilm diagnosis, detection and staging, particularly in clinical settings, however, are still far from mature and may benefit from nanotechnology as well, such as in smart dressing designs and tracer development. This Special Issue of Nanomaterials (Current Impact Factor: 3.504, JCR category rank: 71/285 (Q1) in ‘Materials Science, Multidisciplinary’; 39/92 (Q2) in ‘Nanoscience & Nanotechnology’), “Nanotechnology for Biofilm Prevention, Treatment and Diagnosis”, aims at collecting a compilation of articles that strongly demonstrate the continuous efforts in developing advanced and safe nanomaterial-based technologies to diagnose and fight microbial biofilms.

Dr. Jelmer Sjollema
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biofilm
  • Nano topography
  • Drug delivery
  • Biofilm diagnosis
  • Responsive coatings
  • Multifunctional coatings
  • Microgels
  • Micelles
  • Liposomes
  • Bilayers

Published Papers (1 paper)

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Research

Open AccessArticle
High Stability Thiol-Coated Gold Nanostars Monolayers with Photo-Thermal Antibacterial Activity and Wettability Control
Nanomaterials 2019, 9(9), 1288; https://doi.org/10.3390/nano9091288 - 09 Sep 2019
Abstract
The adhesion and proliferation of bacteria on abiotic surfaces pose challenges in both health care and industrial applications. Gold nanostars (GNSs) monolayers grafted on glass have demonstrated to exert antibacterial action due to their photo-thermal features. Here, these GNS layers were further functionalized [...] Read more.
The adhesion and proliferation of bacteria on abiotic surfaces pose challenges in both health care and industrial applications. Gold nanostars (GNSs) monolayers grafted on glass have demonstrated to exert antibacterial action due to their photo-thermal features. Here, these GNS layers were further functionalized using thiols monolayers, in order to impart different wettability to the surfaces and thus adding a feature that could help to fight bacterial proliferation. Thiol that has different functional groups was used and the thiol-protected surfaces were characterized by means of UV-vis spectroscopy, contact angles, SEM and surface enhanced Raman spectroscopy (SERS). We verified that (i) coating with the proper thiol allows us to impart high hydrophilicity or hydrophobicity to the surfaces (with contact angle values ranging from 10 to 120°); (ii) GNS monolayers are strongly stabilized by functionalization with thiols, with shelf stability increasing from a few weeks to more than three months and (iii) photo-thermal features and subsequent antibacterial effects caused by hyperthermia are not changed by thiols layers, allowing us to kill at least 99.99% of representative bacterial strains. Full article
(This article belongs to the Special Issue Nanotechnology for Biofilm Prevention, Treatment and Diagnosis)
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