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Open AccessArticle

Inhibitory Activity of Silver Nanoparticles Synthesized Using Lycopersicon Esculentum against Biofilm Formation in Candida Species

1
Department of Health and Safety Convergence Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
2
Institute of Health Science, College of Health Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
3
Department of Neurology, Pusan National Yangsan Hospital, Yangsan 50612, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(11), 1512; https://doi.org/10.3390/nano9111512
Received: 23 September 2019 / Revised: 16 October 2019 / Accepted: 20 October 2019 / Published: 23 October 2019
(This article belongs to the Special Issue Nanotechnology for Biofilm Prevention, Treatment and Diagnosis)
This paper investigated the antifungal and antibiofilm activity of silver nanoparticles synthesized with Lycopersicon esculentum extracts against Candida species. Lycopersicon esculentum extracts obtained by homogenization were mixed with silver nitrate to synthesize silver nanoparticles. Analysis of the particle characteristics by UV–Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR) confirmed that the Lycopersicon esculentum extracts effectively served as reductants and capping agents. Minimum inhibitory concentration (MIC) tests were conducted to confirm antifungal activity against Candida species. In all the tested species, the silver nanoparticles inhibited the growth of Candida. Moreover, the SEM images of Candida species treated with silver nanoparticles synthesized using natural extracts of Lycopersicon esculentum showed that silver nanoparticles adhered to the surface of Candida, which induced pore formation in the membranes and prevented their normal growth. Ultimately, these abnormal forms of Candida were thought to be less able to form biofilms than normal Candida. The antifungal and antibiofilm activities of silver nanoparticles against Candida are expected to be utilized in various fields and contribute in particular to developments in nanomedicine. View Full-Text
Keywords: Lycopersicon esculentum; silver nanoparticles; Candida; biofilm Lycopersicon esculentum; silver nanoparticles; Candida; biofilm
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Choi, J.S.; Lee, J.W.; Shin, U.C.; Lee, M.W.; Kim, D.J.; Kim, S.W. Inhibitory Activity of Silver Nanoparticles Synthesized Using Lycopersicon Esculentum against Biofilm Formation in Candida Species. Nanomaterials 2019, 9, 1512.

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