Trigger-Responsive Nanocarriers for Drug Delivery
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: closed (25 July 2020) | Viewed by 8874
Special Issue Editor
Interests: skin penetration of topically applied nanomaterials; skin barrier; hair follicle; follicular penetration pathway and mechanism; skin antisepsis; trigger-responsive nanocarriers for increased drug delivery
Special Issue Information
Dear Colleagues,
Nanocarriers are frequently used for drug delivery in many medical applications. In dermatopharmacy, the implementation of nanocarriers for topical drug delivery is also a hot topic of research, as they provide many advantages, such as the transportation of higher drug concentrations, the improved physical and chemical stability of drugs, and the increased solubility of hydrophobic drugs. The great challenge, however, is that these nanocarriers have to overcome a very potent skin barrier. Nanocarriers themselves are hardly able to overcome an intact skin barrier, but recently several approaches have been developed to use the properties of the nanocarriers in order to improve the bioavailability of topically applied drugs. A very promising approach is the development of trigger-responsive nanocarriers, which are able to release their drug-load upon a specific trigger signal at a specific time point and/or desired location. As trigger signals both endogenous (such as pH, temperature) as well as exogenous signals (such as UV or IR radiation) come into consideration, which provide different advantages and disadvantages. Moreover, trigger-responsive nanocarriers might be an innovative tool to implement nanocarriers not only for dermal but also for systemic drug delivery.
Assoc. Prof. Dr. Alexa Patzelt
Guest Editor
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Keywords
- Nanocarrier
- Topical drug delivery
- Trigger-responsive nanocarrier
- Endogenous trigger signal
- Exogenous trigger signal
- Skin
- Drug delivery
- Dermatopharmacy
- Skin barrier
- Hair follicle
