Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer
AbstractThe chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy. View Full-Text
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Zhang, C.; Wang, Y.; Zhao, Y.; Liu, H.; Zhao, Y.; Li, X.; Lin, Q. Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer. Nanomaterials 2019, 9, 91.
Zhang C, Wang Y, Zhao Y, Liu H, Zhao Y, Li X, Lin Q. Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer. Nanomaterials. 2019; 9(1):91.Chicago/Turabian Style
Zhang, Chuan; Wang, Yuzhuo; Zhao, Yue; Liu, Hou; Zhao, Yueqi; Li, Xiangwei; Lin, Quan. 2019. "Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer." Nanomaterials 9, no. 1: 91.
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