Special Issue "Nanoparticles Assisted Drug Delivery"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (15 October 2015).
Interests: nanoparticles; drug delivery systems; computational modeling; virtual screening
Delivering therapeutic compounds to the target site is a major problem in the treatment of many diseases. Nanocarriers as drug delivery systems (DDSs) are designed to improve the efficacy and to reduce the toxicity of drugs by providing control of biodistribution and pharmacokinetics. Moreover, the combination of active molecules with nanocarriers can protect them against both inactivation and degradation. In comparison with traditional unconjugated drugs, nanocarrier-drug complexes are more effective and selective. As a consequence, the required doses of drugs are lower offering various advantages.
However, despite the large expectations with regards to nanoparticle DDS (nDDSs), they still have several drawbacks and limitations that need to be tackled. For instance, nanocarrier-drug complexes can be phagocytosed by unspecific cells, especially immune cells, giving rise to safety concerns. Moreover, the small size and large surface area can lead to an aggregation, leading to scaling up problems, and making their handling difficult.
Despite all these limitations, nDDSs have a great potential to solve many of the current open issues in drug-treatment. However, to provide a clinically successful DDSs-portfolio, for example, the following challenges have to be overcome: improving biocompatibility, drug loading customization, interaction with biological barriers controlling, immune-defense escape, targeting and release optimization, experimental protocols standardization, and monitoring the exposure level assessing the impact on the environment.
For this Special Issue, we are especially interested in manuscripts that deal with the major classes of nanoparticle platforms: liposomes, polymers, dendrimers, lipid-polymer hybrids, silica, and magnetic nanoparticles. They have to address the aforementioned examples of challenges, with a particular emphasis on their applications in the targeted and controlled delivery of therapeutic molecules, as well as in biocompatibility. This Special Issue invites both experimental and computational-based manuscripts.
Prof. Dr. Andrea Danani
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug delivery system
- targeting therapy