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Erratum published on 14 June 2016, see Nanomaterials 2016, 6(6), 114.
Open AccessArticle

Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery

by Rania Mustafa 1, Yu Luo 1, Yilun Wu 1, Rui Guo 1,* and Xiangyang Shi 1,2,*
1
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
2
CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editors: Subramanian Tamil Selvan and Sebastien Lecommandoux
Nanomaterials 2015, 5(4), 1716-1731; https://doi.org/10.3390/nano5041716
Received: 18 September 2015 / Revised: 7 October 2015 / Accepted: 13 October 2015 / Published: 20 October 2015
(This article belongs to the Special Issue Nanoparticles Assisted Drug Delivery)
In this study, we synthesized dendrimer-functionalized laponite (LAP) nanodisks for loading and delivery of anticancer drug doxorubicin (DOX). Firstly, LAP was modified with silane coupling agents and succinic anhydride to render abundant carboxyl groups on the surface of LAP. Then, poly(amidoamine) (PAMAM) dendrimer of generation 2 (G2) were conjugated to form LM-G2 nanodisks. Anticancer drug DOX was then loaded on the LM-G2 with an impressively high drug loading efficiency of 98.4% and could be released in a pH-sensitive and sustained manner. Moreover, cell viability assay results indicate that LM-G2/DOX complexes could more effectively inhibit the proliferation of KB cells (a human epithelial carcinoma cell line) than free DOX at the same drug concentration. Flow cytometry analysis and confocal laser scanning microscope demonstrated that LM-G2/DOX could be uptaken by KB cells more effectively than free DOX. Considering the exceptional high drug loading efficiency and the abundant dendrimer amine groups on the surface that can be further modified, the developed LM-G2 nanodisks may hold a great promise to be used as a novel platform for anticancer drug delivery. View Full-Text
Keywords: drug delivery system; laponite; PAMAM dendrimer; anticancer efficacy drug delivery system; laponite; PAMAM dendrimer; anticancer efficacy
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MDPI and ACS Style

Mustafa, R.; Luo, Y.; Wu, Y.; Guo, R.; Shi, X. Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery. Nanomaterials 2015, 5, 1716-1731.

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