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Nanomaterials
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Fluorescence Nanoprobes: From Synthesis to Applications
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Fluorescence Nanoprobes: From Synthesis to Applications

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (10 January 2019) | Viewed by 11538

Special Issue Editor

Prof. Dr. Mingqian Tan

E-Mail Website
Guest Editor
Academy of Food Interdisciplinary Science, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian 116034, China
Interests: delivery systems; food nanotechnology; marine food; food functional factor; precision nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fluorescence nanoprobes refer to nanostructures that can re-emit light upon light excitation for the detection of specific target locations and activation, identifying protein interactions and conformation changes in any chemical or biological processes in vitro and in vivo. Fluorescence nanoprobes have shown their unique properties because of their strongly fluorescent signal, excellent photostability, enhanced permeability and retention (EPR) effect, as well as versatile surface chemistry for various applications. The performance of the fluorescence nanoprobes is highly dependent on the design strategy and chemical synthesis methods. This Special Issue of Nanomaterials, “Fluorescence Nanoprobes: From Synthesis to Applications”, aims at collecting research articles that report the design, characterization, and prospective applications of fluorescence nanoprobes in molecular imaging, molecular interaction, image-guided delivery and release, theranostics and various target analysis, in a wide range of research fields, including nanotechnology, biotechnology, biomedical engineering and nanomedicine. The format of full papers, communications, and reviews is welcomed.          

Prof. Dr. Mingqian Tan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescence
  • nanoprobes
  • nanomaterials synthesis and characterizations
  • molecular imaging
  • quantum dots
  • carbon dots
  • surface modification
  • theranostics
  • silica nanoparticles

Published Papers (3 papers)

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Research

12 pages, 4408 KiB  
Article
Carbon Nano-Onions as Non-Cytotoxic Carriers for Cellular Uptake of Glycopeptides and Proteins
by Marta d’Amora, Viviana Maffeis, Rosaria Brescia, Danielle Barnes, Eoin Scanlan and Silvia Giordani
Nanomaterials 2019, 9(8), 1069; https://doi.org/10.3390/nano9081069 - 25 Jul 2019
Cited by 18 | Viewed by 3754
Abstract
Carbon nano-onions (CNOs) possess favorable properties that make them suitable for biomedical applications, including their small size, ready surface modification, and good biocompatibility. Here, we report the covalent immobilization of a synthetic glycopeptide and the protein bovine serum albumin (BSA) onto the surface [...] Read more.
Carbon nano-onions (CNOs) possess favorable properties that make them suitable for biomedical applications, including their small size, ready surface modification, and good biocompatibility. Here, we report the covalent immobilization of a synthetic glycopeptide and the protein bovine serum albumin (BSA) onto the surface of carbon nano-onions using the maleimide–thiol “addition reaction”. The glycopeptide and BSA are readily transported inside different cell lines, together with carbon nano-onions, through the endocytosis pathway. Our results show that carbon nano-onions are excellent scaffolds for glycopeptides and proteins immobilization and act as intracellular carriers for these biomolecules. These findings open new perspectives in the application of carbon nano-onions as intracellular transporters in diverse biomedical applications. Full article
(This article belongs to the Special Issue Fluorescence Nanoprobes: From Synthesis to Applications)
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12 pages, 1596 KiB  
Article
Density Gradient Selection of Colloidal Silver Nanotriangles for Assembling Dye-Particle Plasmophores
by Rui Oliveira-Silva, Mariana Sousa-Jerónimo, David Botequim, Nuno J. O. Silva, Duarte M. F. Prazeres and Pedro M. R. Paulo
Nanomaterials 2019, 9(6), 893; https://doi.org/10.3390/nano9060893 - 18 Jun 2019
Cited by 5 | Viewed by 4404
Abstract
A simple method based on sucrose density gradient centrifugation is proposed here for the fractionation of colloidal silver nanotriangles. This method afforded particle fractions with surface plasmon resonances, spanning from red to infrared spectral ranges that could be used to tune optical properties [...] Read more.
A simple method based on sucrose density gradient centrifugation is proposed here for the fractionation of colloidal silver nanotriangles. This method afforded particle fractions with surface plasmon resonances, spanning from red to infrared spectral ranges that could be used to tune optical properties for plasmonic applications. This feature was exemplified by selecting silver nanotriangle samples with spectral overlap with Atto-655 dye’s absorption and emission in order to assemble dye-particle plasmophores. The emission brightness of an individual plasmophore, as characterized by fluorescence correlation spectroscopy, is at least 1000-fold more intense than that of a single Atto-655 dye label, which renders them as promising platforms for the development of fluorescence-based nanosensors. Full article
(This article belongs to the Special Issue Fluorescence Nanoprobes: From Synthesis to Applications)
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15 pages, 6717 KiB  
Article
Facile Fabrication of Fluorescent Inorganic Nanoparticles with Diverse Shapes for Cell Imaging
by Guifang Wang, Jing Wang, Linlin Zhao, Qiang Zhang and Yan Lu
Nanomaterials 2019, 9(2), 154; https://doi.org/10.3390/nano9020154 - 26 Jan 2019
Cited by 6 | Viewed by 2882
Abstract
In the present work, we describe a facile and general method of fabricating fluorescent inorganic nanoparticles with diverse shapes for cell imaging application. The hematite (α-Fe2O3) nanoparticles (HNPs) with three different shapes (i.e., spindle shape, ellipsoidal shape and quasi-spherical [...] Read more.
In the present work, we describe a facile and general method of fabricating fluorescent inorganic nanoparticles with diverse shapes for cell imaging application. The hematite (α-Fe2O3) nanoparticles (HNPs) with three different shapes (i.e., spindle shape, ellipsoidal shape and quasi-spherical shape) were first prepared as model systems in consideration of good biocompatibility and the controllable morphology of α-Fe2O3. Three fluorescent HNPs with different shapes were readily achieved via one-pot sol-gel reaction of AIE luminogen-functionalized siloxane (AIEgen-Si(OCH3)3) and TEOS in the presence of PVP-stabilized HNPs. Due to the fluorescence originating from the thin AIEgens-contained SiO2 shell around the HNPs, their photoluminescent intensities can be tuned by changing the concentrations of TEOS and AIEgen-Si(OCH3)3 in feed prior to the sol-gel reaction. When the as-prepared fluorescent products were dispersed in water, they gave intense green light emission upon excitation at 360 nm with relatively high fluorescence quantum yield. Further, fluorescent HNPs exhibited low cytotoxicity and excellent photostability and, thus, were used as optical probes to preliminarily explore the effect of nanoparticle shapes on their cellular uptake behaviors. This work should open a facile way to prepare various fluorescent inorganic nanoparticles with specific morphology for various biological applications. Full article
(This article belongs to the Special Issue Fluorescence Nanoprobes: From Synthesis to Applications)
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