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Open AccessArticle

Carbon Nano-Onions as Non-Cytotoxic Carriers for Cellular Uptake of Glycopeptides and Proteins

1
Nano Carbon Materials, Istituto Italiano di Tecnologia (IIT), Via Livorno, 60, 10144 Turin, Italy
2
Electron Microscopy Facility, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy
3
School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, D02 P902 Dublin, Ireland
4
School of Chemical Sciences, Dublin City University (DCU), Glasnevin, D09 C7F8 Dublin, Ireland
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Nanomaterials 2019, 9(8), 1069; https://doi.org/10.3390/nano9081069
Received: 28 June 2019 / Revised: 19 July 2019 / Accepted: 22 July 2019 / Published: 25 July 2019
(This article belongs to the Special Issue Fluorescence Nanoprobes: From Synthesis to Applications)
Carbon nano-onions (CNOs) possess favorable properties that make them suitable for biomedical applications, including their small size, ready surface modification, and good biocompatibility. Here, we report the covalent immobilization of a synthetic glycopeptide and the protein bovine serum albumin (BSA) onto the surface of carbon nano-onions using the maleimide–thiol “addition reaction”. The glycopeptide and BSA are readily transported inside different cell lines, together with carbon nano-onions, through the endocytosis pathway. Our results show that carbon nano-onions are excellent scaffolds for glycopeptides and proteins immobilization and act as intracellular carriers for these biomolecules. These findings open new perspectives in the application of carbon nano-onions as intracellular transporters in diverse biomedical applications. View Full-Text
Keywords: carbon nano-onions; biomolecules; scaffolds; carriers; biomedical applications carbon nano-onions; biomolecules; scaffolds; carriers; biomedical applications
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MDPI and ACS Style

d’Amora, M.; Maffeis, V.; Brescia, R.; Barnes, D.; Scanlan, E.; Giordani, S. Carbon Nano-Onions as Non-Cytotoxic Carriers for Cellular Uptake of Glycopeptides and Proteins. Nanomaterials 2019, 9, 1069.

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