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Nanomaterials
Special Issues
Biodegradable Inorganic Nano-Architectures
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Biodegradable Inorganic Nano-Architectures

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (25 August 2021) | Viewed by 7048

Special Issue Editor

Dr. Valerio Voliani

E-Mail Website1 Website2
Guest Editor
Center for Nanotechnology Innovation, Istituto Italiano di TecnologiaPiazza San Silvestro, 1256127 Pisa, PI, Italy
Interests: nanomedicine; theranostics; antimicrobials; noble metals; oncology; nanotoxicology; biokinetics

Special Issue Information

Dear Colleagues,

Inorganic nanomaterials hold the promise to shift the current medical paradigms in a number of impacting applications, from diagnosis and treatment of neoplasms to inflammations and infections, thanks to their peculiar chemical, physical, and physiological features. Despite massive efforts, treatments based on inorganic nanomaterials are mainly at the preclinical stage, due to the body persistence issue. Indeed, nonbiodegradable materials usually result in long-term persistence within excretion system organs, increasing their likelihood of toxicity.

This Special Issue of Nanomaterials will cover the most recent progresses in the design, production, and application of inorganic nanomaterials that may be able to escape from the organism after the designed action. A special interest is devoted to their biokinetics, biodistribution, and toxicology/biosafety, in order to support the translation of inorganic nanomaterials to the clinical setting.

Dr. Valerio Voliani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biodegradation
  • toxicology
  • cancer
  • nanomedicine
  • synthesis
  • translational research
  • biomaterials
  • combined therapy
  • inflammation
  • diagnostic

Published Papers (2 papers)

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Research

12 pages, 2369 KiB  
Article
Protein Adsorption on SiO2-CaO Bioactive Glass Nanoparticles with Controllable Ca Content
by Martin Kapp, Chunde Li, Zeqian Xu, Aldo R. Boccaccini and Kai Zheng
Nanomaterials 2021, 11(3), 561; https://doi.org/10.3390/nano11030561 - 24 Feb 2021
Cited by 9 | Viewed by 2678
Abstract
Bioactive glass nanoparticles (BGNs) are emerging multifunctional building blocks for various biomedical applications. In this study, the primary aim was to develop monodispersed binary SiO2-CaO BGNs with controllable Ca content. We successfully synthesized such spherical BGNs (size ~110 nm) using a [...] Read more.
Bioactive glass nanoparticles (BGNs) are emerging multifunctional building blocks for various biomedical applications. In this study, the primary aim was to develop monodispersed binary SiO2-CaO BGNs with controllable Ca content. We successfully synthesized such spherical BGNs (size ~110 nm) using a modified Stöber method. Our results showed that the incorporated Ca did not significantly affect particle size, specific surface area, and structure of BGNs. Concentrations of CaO in BGN compositions ranging from 0 to 10 mol% could be obtained without the gap between actual and nominal compositions. For this type of BGNs (specific surface area 30 m2/g), the maximum concentration of incorporated CaO appeared to be ~12 mol%. The influence of Ca content on protein adsorption was investigated using bovine serum albumin (BSA) and lysozyme as model proteins. The amount of adsorbed proteins increased over time at the early stage of adsorption (<2 h), regardless of glass composition and protein type. Further incubation of BGNs with protein-containing solutions seemed to induce a reduced amount of adsorbed proteins, which was more significant in BGNs with higher Ca content. The results indicate that the Ca content in BGNs is related to their protein adsorption behavior. Full article
(This article belongs to the Special Issue Biodegradable Inorganic Nano-Architectures)
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10 pages, 2262 KiB  
Article
A Cost-Effective Approach for Non-Persistent Gold Nano-Architectures Production
by Giulia Giannone, Melissa Santi, Maria Laura Ermini, Domenico Cassano and Valerio Voliani
Nanomaterials 2020, 10(8), 1600; https://doi.org/10.3390/nano10081600 - 14 Aug 2020
Cited by 12 | Viewed by 3723
Abstract
The effective exploitation of the intriguing theranostic features of noble metal nanoparticles for therapeutic applications is far from being a routine practice due to the persistence issue. In this regard, passion fruit-like nano-architectures (NAs), biodegradable and excretable all-in-one, nature-inspired platforms which jointly combine [...] Read more.
The effective exploitation of the intriguing theranostic features of noble metal nanoparticles for therapeutic applications is far from being a routine practice due to the persistence issue. In this regard, passion fruit-like nano-architectures (NAs), biodegradable and excretable all-in-one, nature-inspired platforms which jointly combine these characteristics with the appealing optical behaviors of noble metal nanoparticles, can offer a new alternative for theranostic applications. Besides the need for efficacious and innovative systems, the reliable and cost-effective production of nanomaterials is a pivotal subject for their translation to the clinical setting. Here, we demonstrate the production of a new cheaper class of degradable, ultrasmall-in-nano-architectures (dragon fruit NAs, dNAs) using polyethyleneimine (PEI) as a cationic polymer without affecting either their compositions or their physiological behaviors, compared to the previous NAs. In particular, the standardized protocol characterized in this work ensures the preparation of high gold-loading capacity nanoparticles, a peculiar characteristic that, synergically with the interesting properties of PEI, may unlock new possible applications previously precluded to the first version of NAs while reducing the hand-made production cost by three orders of magnitude. Full article
(This article belongs to the Special Issue Biodegradable Inorganic Nano-Architectures)
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