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Article

A Cost-Effective Approach for Non-Persistent Gold Nano-Architectures Production

1
Center for Nanotechnology [email protected], Istituto Italiano di Tecnologia, Piazza San Silvestro, 12-56127 Pisa, Italy
2
NEST-Scuola Normale Superiore, Piazza San Silvestro, 12-56127 Pisa, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(8), 1600; https://doi.org/10.3390/nano10081600
Received: 10 July 2020 / Revised: 3 August 2020 / Accepted: 11 August 2020 / Published: 14 August 2020
(This article belongs to the Special Issue Biodegradable Inorganic Nano-Architectures)
The effective exploitation of the intriguing theranostic features of noble metal nanoparticles for therapeutic applications is far from being a routine practice due to the persistence issue. In this regard, passion fruit-like nano-architectures (NAs), biodegradable and excretable all-in-one, nature-inspired platforms which jointly combine these characteristics with the appealing optical behaviors of noble metal nanoparticles, can offer a new alternative for theranostic applications. Besides the need for efficacious and innovative systems, the reliable and cost-effective production of nanomaterials is a pivotal subject for their translation to the clinical setting. Here, we demonstrate the production of a new cheaper class of degradable, ultrasmall-in-nano-architectures (dragon fruit NAs, dNAs) using polyethyleneimine (PEI) as a cationic polymer without affecting either their compositions or their physiological behaviors, compared to the previous NAs. In particular, the standardized protocol characterized in this work ensures the preparation of high gold-loading capacity nanoparticles, a peculiar characteristic that, synergically with the interesting properties of PEI, may unlock new possible applications previously precluded to the first version of NAs while reducing the hand-made production cost by three orders of magnitude. View Full-Text
Keywords: nanomaterials; theranostics; gold nanoparticles; production; radio-oncology nanomaterials; theranostics; gold nanoparticles; production; radio-oncology
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MDPI and ACS Style

Giannone, G.; Santi, M.; Ermini, M.L.; Cassano, D.; Voliani, V. A Cost-Effective Approach for Non-Persistent Gold Nano-Architectures Production. Nanomaterials 2020, 10, 1600. https://doi.org/10.3390/nano10081600

AMA Style

Giannone G, Santi M, Ermini ML, Cassano D, Voliani V. A Cost-Effective Approach for Non-Persistent Gold Nano-Architectures Production. Nanomaterials. 2020; 10(8):1600. https://doi.org/10.3390/nano10081600

Chicago/Turabian Style

Giannone, Giulia, Melissa Santi, Maria L. Ermini, Domenico Cassano, and Valerio Voliani. 2020. "A Cost-Effective Approach for Non-Persistent Gold Nano-Architectures Production" Nanomaterials 10, no. 8: 1600. https://doi.org/10.3390/nano10081600

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