Novel Strategies for Nanomaterials for Targeted Drug Delivery

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 6107

Special Issue Editors


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Department of Biochemistry and Physiology, Institute of Nanoscience and Nanotechnology (IN2UB), Universitat de Barcelona, 08007 Barcelona, Spain
Interests: nanotoxicology; nanomaterials; in vitro models
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Guest Editor
Physiology, Department of Biochemistry and Physiology, Universitat de Barcelona, 08028 Barcelona, Spain
Interests: study of antioxidants of natural origin; development of models of ocular and dermal irritation in vitro; development of skin sensitization models in vitro; nanotoxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is a rapid progress in the development of nanotechnologies and nanomaterials, especially their use as nanocarriers for drug delivery. The number of papers related to nanomaterials and drug delivery has increased from no more than 20 in 2000 to more than 6 thousand in the last year. Their small size allows the penetration of drugs into cells in an easier manner. However, these nanomaterials can also facilitate penetration trough more complex systems such as the skin, eyes or the blood–brain barrier or increase the oral bioavailability of drugs with poor solubility, poor permeability, and/or poor stability in the gastrointestinal environment.

Nanocarriers may be tailored to control drug release and/or increase selective cell targeting, cellular uptake, drug solubility, and circulation time in order to maximize the therapeutic effects of drugs and minimize their side effects.

The kind of nanomaterials used with the objective of allowing drug delivery include nanoparticles in a wide variety as nanospheres, micelles, solid lipid nanoparticles, nanoliposomes, dendrimers, magnetic nanoparticles, and nanocapsules.

Nanomaterials for the delivery of anticancer drugs are one of the most studied but there are also other applications, such as the treatment of neurodegenerative and cardiovascular diseases, inflammatory disorders among others.

This Special Issue will cover research in this area with different types of nanomaterials and for different therapeutic purposes.

Prof. Dr. Maria Pilar Vinardell
Prof. Dr. Montse Mitjans Arnal
Guest Editors

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Keywords

  • nanocarriers
  • drug delivery
  • therapy
  • nanovesicles
  • safety

Published Papers (1 paper)

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Review

100 pages, 36761 KiB  
Review
Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms
by Yuzhe Sun and Edward Davis
Nanomaterials 2021, 11(3), 746; https://doi.org/10.3390/nano11030746 - 16 Mar 2021
Cited by 31 | Viewed by 5561
Abstract
To achieve the promise of stimuli-responsive drug delivery systems for the treatment of cancer, they should (1) avoid premature clearance; (2) accumulate in tumors and undergo endocytosis by cancer cells; and (3) exhibit appropriate stimuli-responsive release of the payload. It is challenging to [...] Read more.
To achieve the promise of stimuli-responsive drug delivery systems for the treatment of cancer, they should (1) avoid premature clearance; (2) accumulate in tumors and undergo endocytosis by cancer cells; and (3) exhibit appropriate stimuli-responsive release of the payload. It is challenging to address all of these requirements simultaneously. However, the numerous proof-of-concept studies addressing one or more of these requirements reported every year have dramatically expanded the toolbox available for the design of drug delivery systems. This review highlights recent advances in the targeting and stimuli-responsiveness of drug delivery systems. It begins with a discussion of nanocarrier types and an overview of the factors influencing nanocarrier biodistribution. On-demand release strategies and their application to each type of nanocarrier are reviewed, including both endogenous and exogenous stimuli. Recent developments in stimuli-responsive targeting strategies are also discussed. The remaining challenges and prospective solutions in the field are discussed throughout the review, which is intended to assist researchers in overcoming interdisciplinary knowledge barriers and increase the speed of development. This review presents a nanocarrier-based drug delivery systems toolbox that enables the application of techniques across platforms and inspires researchers with interdisciplinary information to boost the development of multifunctional therapeutic nanoplatforms for cancer therapy. Full article
(This article belongs to the Special Issue Novel Strategies for Nanomaterials for Targeted Drug Delivery)
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