Applications of Fluorescent Nanomaterials in Imaging and Detection

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 896

Special Issue Editors


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Guest Editor
Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Xianyang 712100, China
Interests: application of functional materials in light and electrochemistry; including transdermal therapeutic (TTS); systematic targeting pharmaceutics (STP); visible sensor-guided drug delivery and targeting; fluorescent probes and imaging; visible detection of virus and tumors
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Guest Editor
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China
Interests: visible detection and treatment of tumors; visible sensor-guided drug delivery and targeting; fluorescent probes and imaging; electrochemical sensor

Special Issue Information

Dear Colleagues,

Because of their special structure and optical properties, fluorescent nanomaterials have been rapidly developed and widely used in imaging and detection. At the same time, as an effective analytical method, the sensing and imaging of fluorescent nanomaterials have also brought new opportunities for developing chemistry, physics, medicine, and biology.

The complex environment in organisms has always been a large obstacle to the selectivity of fluorescent probes in biological imaging. The unique characteristics of covalent organic frameworks (COFs), such as excellent stability and biocompatibility, customizable structure, etc., give them great bioimaging potential by shielding interference from irrelevant components. Carbon dots (CDs) have high fluorescence quantum yield(FLQY) advantages, excellent water solubility, chemical stability, biocompatibility, and easy modification, and are widely used in analytical detection, bioimaging, drug delivery, catalysis, and other fields. Semiconductor quantum dots (QDs) are commonly used for intracellular labeling, biosensing, and imaging to study cellular physiological and pathological activities, such as monitoring intracellular protein–protein interactions, disease detection in deep tissue, and cancer biomarkers.

This topic serves as an exciting collection of primary research and review articles on the recent progress in fluorescence nanomaterials in imaging and detection. Submissions may include, but are not limited to, (a) applications of functionalized fluorescent nanomaterials in the detection of different substances; (b) design and preparation of fluorescent nanomaterials with higher properties; (c) development of fluorescent nanomaterials for in vivo and in vitro bioimaging. We hope that the papers collected on this topic may inspire progress in developing fluorescent nanomaterials in imaging and detection applications.

Prof. Dr. Shiguo Sun
Dr. Beibei Hu
Guest Editors

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Keywords

  • fluorescent nanomaterials
  • carbon dots
  • metal nanoparticles
  • quantum dots
  • covalent organic frameworks
  • metal–organic frameworks
  • fluorescence quantum yield
  • bioimaging
  • dual-modality
  • chemosensing
  • biosensing

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Published Papers (1 paper)

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Review

23 pages, 8205 KiB  
Review
Application of NIR Fluorescent Materials in Imaging and Treatment of Tumors of Different Depths
by Mengdi Yu, Xuan Liu, Shuqiong Wang, Ziyao Qin, Beibei Hu, Zhiwei Li and Shiguo Sun
Nanomaterials 2025, 15(11), 811; https://doi.org/10.3390/nano15110811 - 28 May 2025
Viewed by 582
Abstract
Deep-seated tumors present significant diagnostic challenges and pose substantial mortality risks due to their occult anatomical localization. Current diagnostic paradigms predominantly depend on conventional imaging modalities; nevertheless, inherent technical constraints persistently compromise diagnostic precision and therapeutic efficacy. In contrast to traditional methodologies, near-infrared [...] Read more.
Deep-seated tumors present significant diagnostic challenges and pose substantial mortality risks due to their occult anatomical localization. Current diagnostic paradigms predominantly depend on conventional imaging modalities; nevertheless, inherent technical constraints persistently compromise diagnostic precision and therapeutic efficacy. In contrast to traditional methodologies, near-infrared (NIR; 700–1700 nm) fluorescence imaging (FLI) demonstrates superior sensitivity and spatiotemporal resolution, facilitating real-time intraoperative visualization and precision-guided surgical interventions. This paper explores fluorescence materials with tailored structures for tumors at different depths. We critically analyze optimization strategies for NIR fluorescence materials while evaluating their comparative advantages in stratified tissue imaging. This study presents a systematic evaluation of NIR fluorescence molecular tomography (FMT) systems and image reconstruction methodologies. These insights provide feasible ideas for detecting and treating tumors at varying depths in clinical practice. Furthermore, the application of NIR fluorescent materials in tumor diagnosis, navigation-guided surgery, and phototherapy (including photothermal, photodynamic, and immunomodulation therapies) is discussed. Finally, the prospects and challenges of clinical transformation are summarized. Full article
(This article belongs to the Special Issue Applications of Fluorescent Nanomaterials in Imaging and Detection)
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