Toxicology of Nanoparticles

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 26 February 2026 | Viewed by 609

Special Issue Editors

School of Nursing & School of Public Health, Yangzhou University, Yangzhou 225000, China
Interests: nanotoxicology and nanosafety; environmental toxicology
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Guest Editor
School of Public Health, Southeast University, Nanjing 210000, China
Interests: reproductive toxicity based on nanomaterials
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Special Issue Information

Dear Colleagues,

Nanoparticles, which are particles with at least one dimension smaller than 100 nm, hold great potential for advancements in various fields. However, with the increasing prevalence and widespread application of nanoparticles, concerns regarding their potential toxicity have become more pronounced. Despite the utilization of numerous animal models and cell-line-based simulations to assess the toxicity of nanoparticles and elucidate the underlying mechanisms, many aspects of nanotoxicity remain unclear. Therefore, it is imperative to gain a deeper understanding of this issue and identify potential solutions.

The objective of this Special Issue is to compile the most recent advancements in the field of nanoparticle toxicology. Our Special Issue has significant predictive potential for enhancing our comprehension of the potential biological effects, behaviour, and underlying mechanisms of nanoparticles.

This Special Issue will focus on the following topics:

  1. Safety assessment of emerging nanoparticles;
  2. Physiological, cellular, and/or molecular mechanisms underlying the toxicity of nanoparticles;
  3. Screening of low-toxicity or non-toxic nanoparticles;
  4. In vivo transportation and distribution of nanoparticles;
  5. Pharmacological strategies and toxicity prevention measures for nanoparticles;
  6. Ecotoxicological evaluation and model-animal-based toxicology for nanoparticles.

Dr. Man Qu
Dr. Lu Kong
Guest Editors

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Keywords

  • nanotoxicology
  • safety assessment
  • molecular mechanisms
  • emerging nanoparticles
  • nanotoxicity prevention

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Published Papers (1 paper)

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Research

15 pages, 1655 KB  
Article
Sterilization Effects on Liposomes with Varying Lipid Chains
by Sarocha Cherdchom, Krit Pongpirul, Natchanon Rimsueb, Prompong Pienpinijtham and Amornpun Sereemaspun
Nanomaterials 2025, 15(19), 1478; https://doi.org/10.3390/nano15191478 - 27 Sep 2025
Viewed by 510
Abstract
Liposomes, nanoscale vesicles with distinct structural and functional properties, are widely utilized in drug delivery due to their biocompatibility and ability to encapsulate diverse therapeutic agents. Effective sterilization is essential to ensure the safety and efficacy of liposomal formulations in biomedical applications, yet [...] Read more.
Liposomes, nanoscale vesicles with distinct structural and functional properties, are widely utilized in drug delivery due to their biocompatibility and ability to encapsulate diverse therapeutic agents. Effective sterilization is essential to ensure the safety and efficacy of liposomal formulations in biomedical applications, yet its impact on liposome integrity and functionality remains inadequately studied. This work systematically evaluates the effects of three sterilization methods: autoclaving, UV radiation, and filtration—on liposomes composed of dipalmitoylphosphatidylcholine (DPPC) and distearoylphosphatidylcholine (DSPC), two phospholipids differing in lipid chain length. Sterilization altered liposome properties in a lipid chain length-dependent manner, affecting particle size, zeta potential, and phospholipid content. Filtration caused significant hydrocarbon loss, confirmed by Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy, and led to a higher reduction in phospholipid content in DPPC liposomes compared to DSPC liposomes. Biological evaluations showed that autoclaved and UV-irradiated DPPC liposomes exhibited higher cytotoxic and lower stability than their DSPC counterparts. While autoclaving and UV irradiation resulted in minimal chemical alterations, both methods significantly influenced biological properties. Filtration, although less disruptive to biocompatibility, also reduced key liposomal integrity and efficacy. This study underscores the critical importance of post-sterilization evaluation to optimize liposomal formulations for clinical and biomedical use. Full article
(This article belongs to the Special Issue Toxicology of Nanoparticles)
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