Supramolecular Nanostructures for Smart and Tailored Drug Delivery: Recent Progress and Future Perspectives

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 91

Special Issue Editors

E-Mail Website
Guest Editor
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy
Interests: biomedical and biodegradable polymers; polyurethanes; surface functionalisation; tissue engineering; polymeric nanoparticles for nanomedicine; tissue and organ models; additive manufacturing and bioprinting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The term “supramolecular nanostructures” refers to well-defined nano- to meso-scale objects that have resulted from the assembly of ad hoc designed or naturally occurring building blocks held together by non-covalent, directional and reversible interactions (e.g., hydrogen bonding, ionic bonding, dipole forces, hydrophobic interactions and Van der Waals forces or a combination of these). Small molecules (e.g., cyclodextrins), polymers, peptides and proteins are examples of the building blocks available for the fabrication of supramolecular nanostructures. The non-covalent nature of their constituent interactions provides supramolecular nanostructures with additional advantageous features, such as dynamism and stimuli-responsiveness that can be exploited to drive specific responses (e.g., stimuli-responsive drug delivery) while interfacing with biological systems. Overall, supramolecular nanostructures exhibit a wide compositional and chemical versatility, which enables their fine optimization to meet specific requirements (e.g., tailored payload release, active targeting on specific cells, tissues or organs) and pave the way towards the definition of patient personalized therapeutic approaches (e.g., optimal and precise administration of selected payloads according to a well-defined time schedule, depending on patient-specific needs). Furthermore, these structures can enhance the water solubility and bioavailability of drugs, while protecting them from undesired degradation; these problems represent relevant limitations in currently adopted therapeutic approaches.

This Special Issue aims to showcase the latest research and innovations in the design and characterization of supramolecular nanostructures for smart and tailored drug delivery in the biomedical field. Topics of interest include the following: (i) synthesis of new building blocks for supramolecular nanostructure fabrication, (ii) design and characterization of supramolecular nanostructures, and (iii) in-depth investigation into supramolecular nanostructure application in drug delivery, regenerative pharmacology, precision medicine, and beyond.

We invite researchers from around the globe to contribute their original research articles, reviews, and case studies to advance our understanding of supramolecular nanostructures. By fostering collaboration and knowledge exchange in this rapidly evolving field, this Special Issue will provide valuable insights and promote the development of supramolecular nanostructures for smart and tailored drug delivery applications.

We look forward to receiving your contributions and making this Special Issue a valuable resource for researchers and practitioners alike.

Prof. Dr. Gianluca Ciardelli
Dr. Monica Boffito
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • supramolecular nanostructures
  • nanoparticles
  • hydrogels
  • drug delivery
  • nanotechnology
  • precision medicine
  • regenerative pharmacology
  • non-covalent interactions

Published Papers

This special issue is now open for submission.
Back to TopTop