Advances in Chemical Biology of Blood Vessels: From Molecular Interactions to Prospective Targets
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 40
Special Issue Editor
2. Institute for Health and Sport, Immunology and Translational Research Group, Victoria University, Werribee, VIC 3030, Australia
Interests: vascular endothelium; molecular signaling pathways; therapeutic targets; pathophysiological mechanisms; vascular remodeling; cardiovascular therapeutics
Special Issue Information
Dear Colleagues,
The chemical biology of blood vessels investigates the molecular mechanisms driving angiogenesis, vascular permeability, and remodeling. Endothelial cells integrate a myriad of signaling processes to maintain homeostasis. Dysregulation underpins atherosclerosis, tumor angiogenesis, and diabetic vasculopathy. Despite progress using chemoproteomics and activity-based profiling, key gaps persist in defining endothelial heterogeneity, spatiotemporal signaling dynamics, and network crosstalk. Emerging tools, including single-cell multiomics, spatial proteomics, and real-time chemical probes, offer opportunities to address these challenges.
This Special Issue aims to publish recent advances and reviews which critically evaluate unresolved questions, and we seek articles that outline future directions for precision targeting of vascular pathophysiology.
This Special Issue highlights molecular and chemical mechanisms regulating angiogenesis, vascular permeability, and remodeling. Emphasis is placed on endothelial signaling, metabolic and redox control, and innovative tools including chemoproteomics, single-cell multiomics, spatial proteomics, and real-time probes. The Issue addresses endothelial heterogeneity, spatiotemporal signaling, and network crosstalk, guiding future strategies for precision targeting in cardiovascular disease, cancer, and diabetes.
Aligning with the journal’s focus on molecular and chemical biology, the Special Issue emphasizes mechanistic insight, technological innovation, and translational impact, appealing to researchers probing vascular function and developing targeted therapies.
Suggested themes include vascular signaling, metabolism, endothelial heterogeneity, pathophysiology, and chemical biology tools. Article types include original research, reviews, perspectives, and methodological papers.
We look forward to receiving your contributions.
Dr. Anthony Zulli
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chemoproteomics and activity-based profiling
- endothelial signaling and heterogeneity
- angiogenesis and vascular remodeling
- chemical biology spatial proteomics
- real-time chemical probes and dynamic signaling
- precision targeting in cardiovascular disease and cancer
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