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Targeted and Personalized Nanomedicines

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 5552

Special Issue Editors


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Guest Editor
Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
Interests: drug delivery; nanosystems; theranostic materials; nanoimaging; pain nanomedicine; nerve regeneration; targeted immunosupression; organ preservation; acute and chronic inflammation; chronic pain; synthetic chemistry; quality-by-design; nanomedicine manufacturing

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Guest Editor
Life Sciences Department, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy

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Guest Editor
Nanotech Lab, Department Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: nanomedicine; pharmaceutical technology; brain delivery; cancer delivery

Special Issue Information

Dear colleagues,

Personalized nanomedicine aims at the integration of the rapidly expanding toolbox encompassing “omic” disciplines, biotechnology, nanotechnology, and materials science to develop monitoring and therapeutic strategies fulfilling the specific needs of each individual.
The scope of this Special Issue is to collect the most recent advances in the field of nano-enabled personalized medicine, focusing in particular on two of main the areas of nanomedicine, namely targeted delivery systems and diagnostics. This issue will focus primarily on areas of immunology and associated fields. Specifically, we would encourage nanomedicine and precision medicine manuscripts related to cancer biology, immunology, and neuroscience.
One of the key requirements of personalized medicine is the possibility to monitor analytes with technologies coupling low cost and high sensitivity, allowing for reliable and frequent screening. To this end, we will also consider papers describing novel analytical platforms (especially if featuring multiplexing capability) for the detection of biomarkers and metabolites in test solutions and in real biological fluids that could be integrated into portable, wearable biosensors to be operated at the point-of-care. Devices with multiplexing capability, integrating microfluidics or fabricated by innovative approaches (addittive manufacturing) are most welcome.
As pharmaceutical sciences continue to advance nanotechnology for personalized treatments and diagnostics, there is an increased need for high-quality control and cost-effective process design in manufacturing. Therefore, we encourage submissions which specifically focus on pharmaceutical design and manufacturing in nanomedicine and how the advancement of precision medicine is impacted by these efforts.

Dr. Jelena M. Janjic
Dr. Carlo Augusto Bortolotti
Prof. Dr. Giovanni Tosi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical and electronic biosensors
  • multiplexing
  • portable devices
  • point-of-care
  • biological fluids
  • microfluidics
  • nanomedicine design
  • nanomedicine manufacturing
  • quality control
  • colloidal nanosystems
  • nanoimaging
  • targeted nanotechnology

Published Papers (1 paper)

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Research

20 pages, 1533 KiB  
Article
Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale Up
by Michele Herneisey, Eric Lambert, Allison Kachel, Emma Shychuck, James K. Drennen III and Jelena M. Janjic
Molecules 2019, 24(11), 2066; https://doi.org/10.3390/molecules24112066 - 30 May 2019
Cited by 10 | Viewed by 5068
Abstract
The development of pharmaceutical nanoformulations has accelerated over the past decade. However, the nano-sized drug carriers continue to meet substantial regulatory and clinical translation challenges. In order to address some of these key challenges in early development, we adopted a quality by design [...] Read more.
The development of pharmaceutical nanoformulations has accelerated over the past decade. However, the nano-sized drug carriers continue to meet substantial regulatory and clinical translation challenges. In order to address some of these key challenges in early development, we adopted a quality by design approach to develop robust predictive mathematical models for microemulsion formulation, manufacturing, and scale-up. The presented approach combined risk management, design of experiments, multiple linear regression (MLR), and logistic regression to identify a design space in which microemulsion colloidal properties were dependent solely upon microemulsion composition, thus facilitating scale-up operations. Developed MLR models predicted microemulsion diameter, polydispersity index (PDI), and diameter change over 30 days storage, while logistic regression models predicted the probability of a microemulsion passing quality control testing. A stable microemulsion formulation was identified and successfully scaled up tenfold to 1L without impacting droplet diameter, PDI, or stability. Full article
(This article belongs to the Special Issue Targeted and Personalized Nanomedicines)
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