Recent Progress in the Development of Steroid Sulfatase Inhibitors

Dear Colleagues, 

Steroid sulfatase (STS) is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and therefore represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. Despite many treatment strategies that are present today, cancer remains one of the most important medical issues that modern medicine has to face. Considering that numerous carcinomas exhibit a hormone-dependent nature, it is rational to design agents that can block hormone biosynthesis processes. The administration of small molecules exhibiting inhibitory activities against enzymes implicated in hormone biosynthesis may reduce the concentrations of these in tumor tissues and may consequently limit the estrogenic stimulation of cancer cell growth. Currently, STS is recognized as an extremely promising molecular target in the development of effective agents with high therapeutic potential in the treatment of hormone-dependent cancers. Scientists announce discoveries of new molecules demonstrating STS inhibitory properties every year. This Special Issue welcomes original or review papers covering all aspects of steroid sulfatase, its expression, as well as the development of novel STS inhibitors as potential anticancer agents.

Dr. Sebastian Demkowicz
Prof. Dr. Janusz Rachon
Dr. Mateusz Daśko
Guest Editors

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• steroid sulfatase
• steroid sulfatase inhibitors
• STS Expression
• natural compounds
• coumarin
• sulfamate derivatives